15 February 2021>: Clinical Research
Polymorphisms in and Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population
Yuqin Peng BC , Bingqian Chen BCD , Xiaowen Sheng DE , Yufeng Qian AEG*DOI: 10.12659/MSM.928455
Med Sci Monit 2021; 27:e928455
Table 3 The association between the alleles of IRF5 and TYK2 gene polymorphisms and RA risk.
SNP (A/B) | Position | Case (N=578) | Control (N=578) | P (B vs A+B) | OR (95% CI) | |
---|---|---|---|---|---|---|
Exon 6 (D/I) | Exon 6 | 602 | 554 | 0.05 | 0.85 [0.72–0.99] | |
rs2070197(T/C) | 3′-UTR | 7 | 3 | 0.21 | 2.34 [0.60–9.07] | |
rs10954213(A/G) | 3′-UTR | 371 | 370 | 0.96 | 1.00 [0.84–1.20] | |
rs2004640(G/T) | Exon 1 | 290 | 221 | 0.0003 | 1.43 [1.17–1.74] | |
rs280500(G/A) | 5′ UTR | 342 | 260 | 0.0001 | 1.45 [1.20, 1.75] | |
rs280519(A/G) | Intron | 573 | 522 | 0.03 | 0.84 [0.71–0.98] | |
rs280521(G/A) | Intron | 279 | 170 | 1.06e-008 | 1.85 [1.49–2.28] | |
rs8108236(G/A) | Intron | 313 | 237 | 0.0002 | 1.44 [1.19–1.75] | |
rs12720253(T/G) | Intron | 81 | 105 | 0.07 | 0.75 [0.56–1.02] | |
SNP – single nucleotide polymorphism; OR – odds ratio, 95% CI – 95% confidence intervals; de(D)/in(I) – deletion/insertion; UTR – untranslated region; A – allele with major frequency; B – allele with minor frequency. |