15 February 2021: Clinical Research
Polymorphisms in and Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population
Yuqin Peng BC , Bingqian Chen BCD , Xiaowen Sheng DE , Yufeng Qian AEG*DOI: 10.12659/MSM.928455
Med Sci Monit 2021; 27:e928455
Table 2 Distributions of the genotypes of IRF5 and TYK2 polymorphisms in cases and controls.
| Genes | SNP (A/B) | Genotype (AA/AB/BB) | Genotype frequencies (%) | a P, OR (95% CI) (AB+BB vs AA) | b P, OR (95% CI) (BB vs AA+AB) | Power | |
|---|---|---|---|---|---|---|---|
| Cases | Controls | ||||||
| Exon 6 (D/I) | DD/DI/II | 138/278/162 | 157/288/133 | 0.20, 1.19 [0.91, 1.55] | 0.05, 1.30 [1.00, 1.70] | 95.6 | |
| rs2070197(T/C) | TT/CT/CC | 571/7/0 | 575/3/0 | 0.22, 2.35 [0.60, 9.13] | NA | ||
| rs10954213(A/G) | AA/GA/GG | 277/231/70 | 265/256/57 | 0.48, 0.92 [0.73, 1.16] | 0.22, 1.26 [0.87, 1.82] | ||
| rs2004640(G/T) | GG/GT/TT | 317/232/29 | 371/193/14 | 0.001, 1.49 [1.17, 1.88] | 0.01, 2.30 [1.18, 4.46] | ||
| rs280500(G/A) | GG/AG/AA | 277/260/41 | 347/202/29 | 0.0001, 1.63 [1.29, 2.06] | 0.14, 1.45 [0.89, 2.36] | ||
| rs280519(A/G) | AA/GA/GG | 157/269/152 | 182/270/126 | 0.11, 1.23 [0.96, 1.59] | 0.07, 1.28 [0.98, 1.68] | ||
| rs280521(G/A) | GG/AG/AA | 324/229/25 | 423/140/15 | 1.35e-008, 2.14 [1.67, 2.74] | 0.11, 1.70 [0.89, 3.25] | ||
| rs8108236(G/A) | GG/AG/AA | 311/221/46 | 372/175/31 | 0.0003, 1.55 [1.22, 1.96] | 0.08, 1.53 [0.95, 2.44] | ||
| rs12720253(T/G) | TT/GT/GG | 499/77/2 | 475/101/2 | 0.05, 0.73 [0.53, 1.00] | 1.00, 1.00 [0.14, 7.12] | ||
| a P dominant model; b P –recessive model; SNP – single nucleotide polymorphism; OR – odds ratio, 95% CI – 95% confidence intervals, NA – not available; de(D)/in(I) – deletion/insertion; A – allele with major frequency; B – allele with minor frequency. | |||||||