03 March 2021>: Animal Study
A Network Pharmacology Study of the Molecular Mechanisms of in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model
Sen Ling Feng 1ACE* , Jing Zhang 2BCEF* , Hongliu Jin 1BC , Wen Ting Zhu 1BC , Zhongwen Yuan 1ABCDEFG*DOI: 10.12659/MSM.928402
Med Sci Monit 2021; 27:e928402
Table 4 The node characteristic parameters of the main targets in the compound-target network.
Target | Target name | Degree | Betweenness | Closeness |
---|---|---|---|---|
PTGS2 | Prostaglandin G/H synthase 2 | 17 | 0.240087 | 0.525822 |
NOS3 | Nitric oxide synthase, endothelial | 6 | 0.021565 | 0.435798 |
PPARG | Peroxisome proliferator activated receptor gamma | 5 | 0.009116 | 0.425856 |
DPP4 | Dipeptidyl peptidase IV | 5 | 0.020751 | 0.432432 |
BCL2 | Apoptosis regulator Bcl-2 | 4 | 0.006814 | 0.413284 |
TNF | Tumor necrosis factor | 4 | 0.011948 | 0.410256 |
PIK3CG | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform | 4 | 0.008965 | 0.416357 |
F10 | Coagulation factor X | 4 | 0.028392 | 0.422642 |