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03 March 2021: Animal Study

A Network Pharmacology Study of the Molecular Mechanisms of in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model

Sen Ling Feng 1ACE* , Jing Zhang 2BCEF* , Hongliu Jin 1BC , Wen Ting Zhu 1BC , Zhongwen Yuan 1ABCDEFG*

DOI: 10.12659/MSM.928402

Med Sci Monit 2021; 27:e928402

Table 4 The node characteristic parameters of the main targets in the compound-target network.

TargetTarget nameDegreeBetweennessCloseness
PTGS2Prostaglandin G/H synthase 2170.2400870.525822
NOS3Nitric oxide synthase, endothelial60.0215650.435798
PPARGPeroxisome proliferator activated receptor gamma50.0091160.425856
DPP4Dipeptidyl peptidase IV50.0207510.432432
BCL2Apoptosis regulator Bcl-240.0068140.413284
TNFTumor necrosis factor40.0119480.410256
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform40.0089650.416357
F10Coagulation factor X40.0283920.422642

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750