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03 March 2021: Animal Study

A Network Pharmacology Study of the Molecular Mechanisms of in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model

Sen Ling Feng 1ACE* , Jing Zhang 2BCEF* , Hongliu Jin 1BC , Wen Ting Zhu 1BC , Zhongwen Yuan 1ABCDEFG*

DOI: 10.12659/MSM.928402

Med Sci Monit 2021; 27:e928402

Table 2 The active components of Hypericum japonicum.

MOL IDMolecule nameMWOB%DL
MOL000069Palmitic acid256.4819.30.1
MOL000098Quercetin302.2546.430.28
MOL000105Protocatechuic acid154.1325.370.04
MOL000114Vanillic acid168.1635.470.04
MOL000166ZINC01609418222.4121.620.07
MOL000193(Z)-caryophyllene204.3930.290.09
MOL000211Mairin456.7855.380.78
MOL000358beta-sitosterol414.7936.910.75
MOL000359Sitosterol414.7936.910.75
MOL000414Caffeate180.1754.970.05
MOL000422Kaempferol286.2541.880.24
MOL000437Hirsutrin464.411.860.77
MOL000676DBP278.3864.540.13
MOL000701Quercitrin448.414.040.74
MOL000861Healip326.6811.650.22
MOL001955Heriguard354.3411.930.33
MOL002067Hypericin504.4614.660.08
MOL002378UND156.3517.150.02
MOL002622Filicin668.86.710.63
MOL003228Norathyriol260.2118.350.22
MOL004459Tridecanol200.4115.180.04
MOL004746(E,7S,11R)-3,7,11,15-tetramethylhexadec-2-en-1-ol296.633.820.13
MOL004783Nonane128.2929.230.01
MOL005810Lauryl palmitate424.8414.450.43
MOL006771Poriferasterol monoglucoside574.9321.320.63
MOL006772Poriferasterol monoglucoside_qt412.7743.830.76
MOL007860Quercetin-7-rhamnoside448.4115.50.76
MOL007861Sarothralin534.654.240.72
MOL007862Uliginosin B498.6228.10.73
MOL007863Saroaspidin A446.545.740.48
MOL007864Saroaspiden B460.5721.450.52
MOL007865Saroaspiden C474.65.570.55
MOL007866Japonicin A460.5715.80.5
MOL007867Japonicine B566.753.920.78
MOL007868Japonicine C534.654.220.72
MOL007869Japonicine D668.81.60.64
MOL007870Sarothralen A568.770.970.69
MOL007871Sarothralin G602.780.960.7
MOL007872Quercetin-7-O-rhamnoside448.412.60.76
MOL007873Isoamyl laurate270.5123.920.11
MOL007874Lauryl stearate452.913.920.46
MOL007875Mesylmethane94.1540.120.00
MOL0078762,4-dimethylheptane128.2935.90.01
MOL007877n-Tetra-triacontanoic acid530.6910.540.5
MOL0078784H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-3-(alpha-D-galactopyranosyloxy)-5,7-dihydroxy-464.412.410.77
MOL007879Tetramethoxyluteolin342.3443.680.37
MOL0078803,5,7,3′,5′ pentahydroxy flavonol290.2963.640.24
MOL0078811,3,5,6-tetrahydroxyxanthone260.2116.220.22
MOL007882Xanthone der.244.2118.160.19

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750