29 May 2021>: Lab/In Vitro Research
Silencing Ribosomal Protein L22 Promotes Proliferation and Migration, and Inhibits Apoptosis of Gastric Cancer Cells by Regulating the Murine Double Minute 2-Protein 53 (MDM2-p53) Signaling Pathway
Zhenqing Sun 1ABCE* , Zhigang Qiu 1ABCE* , Zhengkun Wang 1DE , Honghui Chi 2DE , Peipei Shan 3CE*DOI: 10.12659/MSM.928375
Med Sci Monit 2021; 27:e928375
Table 2 Correlation between the expression of RPL22 and clinicopathological features of gastric cancer patients.
Parameter | Number (N=40) | RPL22 mRNA expression | P value |
---|---|---|---|
Age (years) | |||
7 | 0.6618±0.1622 | 0.9766 | |
≥50 | 33 | 0.6700±0.1226 | |
Gender | |||
Male | 22 | 0.7084±0.1370 | 0.6191 |
Female | 18 | 0.6199±0.0994 | |
Stage | |||
Early stage | 29 | 0.7370±0.0692 | 0.0372* |
Advanced stage | 11 | 0.4883±0.0347 | |
Lymphatic metastasis | |||
No | 23 | 0.7301±0.0450 | 0.0212* |
Yes | 17 | 0.5723±0.0501 | |
Tumor position | |||
Cardia | 6 | 0.4996±0.0089 | 0.7469 |
Gastric fundus | 5 | 0.6793±0.1779 | |
Antrum | 22 | 0.7101±0.1096 | |
Gastric angle | 7 | 0.7046±0.0686 | |
Degree of histological type | |||
Good | 9 | 0.6633±0.1669 | 0.9995 |
Moderate | 6 | 0.6688±0.0892 | |
Poor | 25 | 0.6704±0.1253 | |
RPL22 – ribosomal proteins L22; * represented significantly different at |