20 January 2021: Meta-Analysis
Association Between Mitochondrial DNA Copy Number and Head and Neck Squamous Cell Carcinoma: A Systematic Review and Dose-Response Meta-Analysis
Zhu Zhu 1ABCDEF , Yixiu Liu 2B , Didi Wu 1C , Hongpeng Wang 2ABCDEF*DOI: 10.12659/MSM.928327
Med Sci Monit 2021; 27:e928327
Table 2 Subgroup analyses for the two class meta-analysis.
| Studies | N. of Studies | SMD (95% CI) | Heterogeneity (I2; P value) | N. of studies | OR (95% CI) | Heterogeneity (I2; P value) |
|---|---|---|---|---|---|---|
| All studies | 9 | 0.71 (0.28–1.15) | 96.8%; | 4 | 0.87 (0.52–1.44) | 82.5%; 0.001 |
| Study design | ||||||
| Cohort | 2 | 1.18 (−0.02,2.38) | 95.8%; | – | ||
| Case-control | 7 | 0.58 (0.11,1.04) | 96.8%; | 4 | 0.87 (0.52–1.44) | 82.5%; 0.001 |
| Sample | ||||||
| PBL | 4 | 0.33 (0.06–0.60) | 83.7%; | 3 | 1.03 (0.61–1.73) | 79.9%; 0.007 |
| Tissues | 2 | 0.76 (−1.27,2.79) | 98.8%; | 1 | 0.52 (0.30–0.87) | – |
| Saliva | 3 | 1.33 (−0.06,2.72) | 98.6%; | – | ||
| Region | ||||||
| China | 3 | 0.91 (0.16–1.66) | 95.9%; | 1 | 1.06 (0.84–1.34) | – |
| India | 2 | −0.26 (−0.45 – −0.07) | 0%; 0.884 | 2 | 0.51 (0.34–0.77) | 0%; 0.938 |
| America | 4 | 1.10 (0.23,1.97) | 98.0%; | 1 | 1.69 (1.14–2.51) | – |
| mtDNA gene | ||||||
| ND1 | 3 | 0.88 (0.30–1.46) | 95.9%; | 2 | 1.30 (0.83–2.05) | 74.9%; 0.046 |
| D-loop | 2 | −0.26 (−0.45 – −0.07) | 0%; 0.884 | 2 | 0.51 (0.34–0.77) | 0%; 0.938 |
| Cox I/Cox II | 3 | 1.33 (−0.06–2.72) | 98.6%; | – | ||
| tRNA-leu | 1 | 0.57 (0.25–0.90) | – | – | ||
| NOS score | ||||||
| 1 | 3.79 (3.22–4.35) | – | – | |||
| 6 | 6 | 0.35 (−0.13–0.84) | 94.9%; | 2 | 0.51 (0.34–0.77) | 0%; 0.938 |
| >6 | 2 | 0.44 (0.33–0.54) | 2.4%; 0.311 | 2 | 1.30 (0.83–2.05) | 74.9%; 0.046 |
| N – number; SMD – standardized mean differences; OR – odds ratio; CI – confidence interval; PBL – peripheral blood lymphocytes; Cox – cytochrome c oxidase; NOS – Newcastle-Ottawa Quality Assessment Scale. | ||||||