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15 January 2021: Review Articles

Alterations in Cerebral Hemodynamics During Microgravity: A Literature Review

Jichen Du 1ADE* , Jiangbo Cui 2BC , Jing Yang 1D , Peifu Wang 1B , Lvming Zhang 1D , Bin Luo 1BDF , Bailin Han 1E

DOI: 10.12659/MSM.928108

Med Sci Monit 2021; 27:e928108

Table 2 Impact of simulated or actual microgravity on cerebral blood flow and cerebral blood flow velocity.

AuthorsnExperimental protocolConclusion
Kawai et al. []28 824h, −6° HDBR, TCD, rMCACBFv increased at 0.5h of HDBR, during upright seated recovery, CBFv decreased when compared with baseline, and CBFv positively correlated with IAP
Sun et al. []29 1221 days, −6° HDBR, TCD, rMCACBFv decreased since day 1 and dropped further on day 3 until reaching a minimum value on day 21
Arbeille et al. []30 2460 days, −6° HDBR, TCD, rMCACBFv significantly decreased on day 55
Iwasaki et al. []31 616 days, space mission, TCD, MCAResting CBFv did not change significantly from preflight values during or after spaceflight
Klein et al. []33 1715 bouts of 22s intervals Parabolic flight, TCD, rMCAWith decreased MAP and increased CO, CBFv remained unchanged in the microgravity condition
Ogoh et al. []34 103 days, DI, TCD, rICA, rECA, rVACBFv in ICA, ECA and VA did not change. A decreased cardiac output associated with CBFv in ICA and VA but not ECA
Marshall-Goebel et al. []35 93 h, −6°, −12°, −18° HDBR, MRI, bilateral ICA and VACBFv in ICA decreased at each tilt degree, CBFv in VA did not changed
Ogoh et al. []36 1060 days, −6° HDBR, TCDCBFv in ICA decreased on day 30, returned to baseline on day 57; CBFv in VA remained unaltered throughout HDBR; CBFv in ECA increased on day 30 and 57, indicating long-term microgravity may induce heterogeneous responses in cerebral circulation
CBF – cerebral blood flow; CBFv – cerebral blood flow velocity; HDBR – head-down bed rest; rMCA – right middle cerebral artery; rICA – right internal carotid artery; rECA – right external carotid artery; rVA – right vertebral artery; IAP – intracranial arterial pressure; DI – dry immersion.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750