Alterations in Cerebral Hemodynamics During Microgravity: A Literature Review

15 January 2021: Review Articles

Jichen Du ^1ADE* , Jiangbo Cui ^2BC , Jing Yang ^1D , Peifu Wang ^1B , Lvming Zhang ^1D , Bin Luo ^1BDF , Bailin Han ^1E

DOI: 10.12659/MSM.928108

Med Sci Monit 2021; 27:e928108

Table 1 Impact of simulated or actual microgravity on intracranial pressure.

Authors	n	Experimental protocol	Conclusion
Kermorgant et al. []¹⁶	12	3 days of DI	3 days of DI, induced an enlarged ONSD, a surrogate value for estimated ICP
Mader et al. []²¹	1	6 months of spaceflight	After returned to earth, ICP elevated to 22 mmHg and remained high for a period of time
Avan et al. []²²	40	Parabolic flight	Moderate increased ICP during microgravity
Lawley et al. []¹⁹	8	Parabolic flight and 24 h −6° HDBR	HDBR does not progressively increase ICP, but microgravity does prevent the normal lowering of ICP when upright
Arbeille et al. []²³	10	2 h of DI	Due to large individual variability, no substantial changes in ICP have been observed
ICP – intracranial pressure; ONSD – optic nerve sheath diameter; DI – dry immersion; ISS – international space station; HDBR – head-down bed rest.