Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

04 February 2021: Database Analysis

High Expression of the Component 3a Receptor 1 (C3AR1) Gene in Stomach Adenocarcinomas Infers a Poor Prognosis and High Immune-Infiltration Levels

Haibo Yang 1ABCDF , Lin Li 2BD , Xiaoyu Liu 1B , Yu Zhao 1ADG*

DOI: 10.12659/MSM.927977

Med Sci Monit 2021; 27:e927977

Table 2 Correlation between C3AR1 and immune markers in STAD by TIMER and GEPIA database.

DescriptionGene markersTIMERGEPIA
rP-valuerP-value
CD8+T CellCD8A0.552*** 0.57***
CD8B0.342*** 0.37***
B CellCD190.285*** 0.24***
CD79A0.373*** 0.34***
MonocyteCD860.909*** 0.92***
CD115(CSF1R)0.902*** 0.9***
TAMsCCL20.522*** 0.55***
CD680.661*** 0.73***
IL100.704*** 0.75***
M1 macrophageINOS(NOS2)0.113* 0.15**
IRF50.342*** 0.4***
COX2(PTGS2)0.074.0.17***
M2 macrophageCD1630.903*** 0.83***
VSIG40.865*** 0.87***
MS4A4A0.923*** 0.93***
Dendritic CellsHLA-DPB10.661*** 0.69***
HLA-DQB10.515*** 0.4***
HLA-DRA0.698*** 0.71***
HLA-DPA10.696*** 0.7***
BDCA-1(CD1C)0.46*** 0.45***
BDCA-4(NRP1)0.587*** 0.64***
CD11c (ITGAX)0.814*** 0.8***
NK CellsKIR2DL10.366*** 0.37***
KIR2DL30.326*** 0.46***
KIR2DL40.299*** 0.3***
KIR3DL10.286*** 0.35***
KIR3DL20.31*** 0.37***
KIR3DL30.077.0.048.
KID2DS40.253***
T Cell (general)CD3D0.566*** 0.55***
CD3E0.53*** 0.54***
CD20.652*** 0.67***
Th1T-bet (TBX21)0.563*** 0.58***
STAT40.624*** 0.62***
STAT10.343*** 0.45***
IFN-γ (IFNG)0.423*** 0.45***
TNF-α (TNF)0.279*** 0.33***
Th2GATA30.417*** 0.44***
STAT60.019.0.016**
STAT5A0.465*** 0.55***
IL130.133** 0.19***
TfhBCL60.3*** 0.4***
IL210.435*** 0.49***
Th17STAT30.365*** 0.45***
IL17A0.007.0.031.
Treg cellsFOXP30.562*** 0.59***
CCR80.665*** 0.71***
STAT5B0.346*** 0.48***
TGF-β0.453*** 0.5***
NeutrophilsCD66B0.064.0.069.
CD11b0.784*** 0.77***
CCR70.492*** 0.51***
Exhaustion T cellsTIM-3 (HAVCR2)0.907*** 0.92***
TIGIT0.57*** 0.6***
GZMA0.553*** 0.56***
LAG-30.501*** 0.49***
CTLA40.478*** 0.54***
PD-1 (PDCD1)0.467*** 0.49***
TAMs – tumor-associated macrophages; NK cells – natural killer cells; Th1, Th2, Tfh, Th17 – helper T cell subtypes. ≥0.05,
*
**
***

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750