12 November 2020: Clinical Research
Red Blood Cell Distribution Width-to-Platelet Ratio and Other Laboratory Indices Associated with Severity of Histological Hepatic Fibrosis in Patients with Autoimmune Hepatitis: A Retrospective Study at a Single Center
Xu Li 1BCE , Hongqin Xu 12CD , Pujun Gao 1AG*DOI: 10.12659/MSM.927946
Med Sci Monit 2020; 26:e927946
Table 2 Univariate and multivariate analyses of variables associated with autoimmune hepatitis-related liver fibrosis.
| Variables | No/minimal fibrosis, N=45 | Advanced fibrosis, N=27 | P# | AOR (95% CI)* | P** |
|---|---|---|---|---|---|
| Sex | 0.439 | – | – | ||
| Female, N (%) | 39 (86.7) | 25 (92.6) | |||
| Male, N (%) | 6 (13.3) | 2 (7.4) | |||
| Age(years) | 0.427 | – | – | ||
| 26 (57.8) | 13 (48.1) | ||||
| ≥55 | 19 (42.2) | 14 (51.9) | |||
| History of medication | 0.950 | – | – | ||
| No, N (%) | 28 (62.2) | 17 (63.0) | |||
| Yes, N (%) | 17 (37.8) | 10 (37.0) | |||
| History of autoimmune disease | 0.708 | – | – | ||
| No, N (%) | 35 (77.8) | 22 (81.5) | |||
| Yes, N (%) | 10 (22.2) | 5 (18.5) | |||
| Smoking | 0.281 | – | – | ||
| No, N (%) | 43 (95.6) | 24 (88.9) | |||
| Yes, N (%) | 2 (4.4) | 3 (11.1) | |||
| Drinking | 0.826 | – | – | ||
| No, N (%) | 41 (91.1) | 25 (92.6) | |||
| Yes, N (%) | 4 (8.9) | 2 (7.4) | |||
| Diabetes | 0.879 | – | – | ||
| No, N (%) | 43 (95.6) | 26 (96.3) | |||
| Yes, N (%) | 2 (4.4) | 1 (3.7) | |||
| GLO (g/L) | 35.80 (30.00,42.50) | 36.40 (31.60,44.80) | 0.587 | – | – |
| IgG (g/L) | 20.40 (16.00, 24.20) | 20.80 (17.00,24.30) | 0.697 | ||
| IgA (g/L) | 2.84 (2.09, 3.91) | 3.94 (3.10,5.78) | 0.001 | 1.609 (1.028–2.517) | 0.037 |
| RDW (%) | 14.40 (13.20, 15.45) | 15.60 (14.20, 17.70) | 0.010 | ||
| AAR | 0.91 (0.69,1.62) | 1.25 (0.95,1.79) | 0.039 | ||
| APRI | 2.04 (0.96,4.87) | 2.67 (1.54,4.99) | 0.267 | ||
| FIB-4 | 4.06 (2.03,6.04) | 5.92 (3.96,11.36) | 0.004 | ||
| GPR | 1.08 (0.48,1.66) | 1.16 (0.78,2.49) | 0.161 | 1.638 (1.014–2.647) | 0.044 |
| NLR | 1.29 (0.90,1.96) | 1.71 (1.26,2.09) | 0.053 | ||
| RLR | 7.86 (5.69,10.83) | 12.23 (7.95,18.06) | 0.004 | ||
| RPR (ln) | −2.53 (−2.77, −2.32) | −2.09 (−2.30, −1.53) | 25.507 (2.934–221.784) | 0.003 | |
| Continuous variables are expressed as median (25, 75 percentiles). Categorical variables are displayed as numbers and percentages. # value for Univariate analysis; * Adjusted for Sex, age, smoking, drinking, history of medication, history of autoimmune disease, presence of diabetes mellitus, GLO, IGG, IGA, RDW, AAR, APRI, FIB-4, GPR, NLR, RLR, and RPR; ** value for multivariate analysis. AAR – aspartate aminotransferase to alanine aminotransferase ratio; APRI – AST to PLT ratio index; Fib-4 – fibrosis-4 index; GPR – GGT to PLT ratio; NLR – neutrophil to lymphocyte ratio; RLR – RDW to lymphocyte ratio, RPR – RDW to PLT ratio. RPR levels are expressed as lnN units. | |||||