12 November 2020: Clinical Research
Red Blood Cell Distribution Width-to-Platelet Ratio and Other Laboratory Indices Associated with Severity of Histological Hepatic Fibrosis in Patients with Autoimmune Hepatitis: A Retrospective Study at a Single Center
Xu Li 1BCE , Hongqin Xu 12CD , Pujun Gao 1AG*DOI: 10.12659/MSM.927946
Med Sci Monit 2020; 26:e927946
Table 1A Demographic characteristics of autoimmune hepatitis group and drug-induced liver injury group.
| Variable | AIH N=72 | DILI N=164 | P |
|---|---|---|---|
| Male, N(%) | 8 (11.1) | 40 (24.4) | 0.020 |
| Age (years) | 54.00 (48.25, 62.75) | 50.00 (42.00, 56.00) | 0.004 |
| Smoking, N (%) | 5 (6.9) | 24 (14.6) | 0.098 |
| Drinking, N (%) | 6 (8.3) | 20 (12.2) | 0.383 |
| History of medication, N (%) | 27 (37.5) | 164 (100) | |
| History of autoimmune disease, N (%) | 15 (20.8) | 0 (0.0) | |
| Diabetes, N (%) | 3 (4.2) | 14 (8.5) | 0.232 |
| AST (IU/L) | 119.95 (77.25, 324.15) | 117.80 (46.55, 230.60) | 0.146 |
| ALT (IU/L) | 137.55 (59.90, 270.50) | 164.35 (55.03, 330.85) | 0.369 |
| TBIL (μmol/L) | 37.55 (18.25, 118.15) | 29.40 (13.70,122.13) | 0.632 |
| ALP (IU/L) | 152.70 (119.75, 278.73) | 121.90 (96.80,189.78) | 0.002 |
| GGT (IU/L) | 152.10 (86.53, 285.90) | 147.65 (77.40, 275.53) | 0.828 |
| ALB (g/L) | 34.70 (30.28,38.25) | 37.45 (34.63,40.90) | |
| GLO (g/L) | 36.05 (31.23,43.98) | 28.40 (24.60,31.85) | |
| TBA (μmol/L) | 50.50 (17.85,150.55) | 25.70 (8.20,138.30) | 0.032 |
| WBC (10/L) | 4.81 (3.69,6.10) | 4.98 (3.94,6.47) | 0.360 |
| Neutrophil (10/L) | 2.33 (1.72,3.19) | 2.74 (1.96,3.59) | 0.070 |
| Lymphocyte (10/L) | 1.62 (1.18,2.40) | 1.69 (1.24,2.19) | 0.974 |
| HGB (g/L) | 123.00 (114.25,132.75) | 128.00 (120.00–140.00) | 0.009 |
| RDW (%) | 14.85 (13.30,16.08) | 14.30 (13.10, 15.83) | 0.096 |
| PLT (10/L) | 163.50 (126.25,202.75) | 201.00 (164.00, 253.00) | |
| PT(s) | 11.90 (11.20,13.60) | 11.45 (10.80, 12.40) | 0.006 |
| DILI – drug-induced liver injury; AIH – autoimmune hepatitis; WBC – white blood cell; HGB – hemoglobin; RDW – red blood cell distribution width; PLT – platelet counts; AST – aspartate aminotransferase; ALT – alanine aminotransferase; GGT – gamma glutamyl transferase; ALP – alkaline phosphatase; TBIL – total bilirubin; TBA – total bile acid; ALB – albumin; GLO – globulin; PT – prothrombin time. Continuous variables are expressed as median (25, 75 percentiles). Categorical variables were displayed as numbers and percentages. | |||