19 January 2021: Database Analysis
Bioinformatics Analysis of Differentially Expressed Genes and Protein–Protein Interaction Networks Associated with Functional Pathways in Ulcerative Colitis
Feng Cao AE* , Yun-Sheng Cheng E* , Liang Yu D , Yan-Yan Xu AG* , Yong Wang A*DOI: 10.12659/MSM.927917
Med Sci Monit 2021; 27:e927917
Table 2 The main signaling pathway enrichment analysis of the top 3 hub genes.
| Pathway identifier | Pathway name | P value | FDR | Genes |
|---|---|---|---|---|
| R-HSA-6783783 | Interleukin-10 signaling | 1.11E-16 | 3.11E-15 | CXCL8; CCL20; IL1B; CXCL1; TIMP1; PTGS2 |
| R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling | 1.11E-16 | 3.11E-15 | SOCS3; CXCL8; NOS2; MMP1; IL1B; MMP3; LCN2; TIMP1; PTGS2 |
| R-HSA-449147 | Signaling by Interleukins | 1.11E-16 | 3.11E-15 | SOCS3; CXCL8; NOS2; MMP1; CCL20; IL1B; MMP3; LCN2; CXCL1; TIMP1; PTGS2 |
| R-HSA-1280215 | Cytokine signaling in immune system | 1.11E-16 | 3.11E-15 | SOCS3; CXCL8; NOS2; MMP1; CCL20; IL1B; MMP3; LCN2; CXCL1; TIMP1; PTGS2 |
| R-HSA-168256 | Immune system | 9.20E-13 | 2.02E-11 | CXCL8; NOS2; MMP1; CCL20; MMP3; CXCL1; PTGS2; C3; SOCS3; IL1B; LCN2; CHI3L1; TIMP1 |
| R-HSA-380108 | Chemokine receptors bind chemokines | 6.46E-09 | 1.03E-07 | CXCL11; CXCL8; CCL20; CXCL1; CXCL13 |
| R-HSA-375276 | Peptide ligand-binding receptors | 7.91E-07 | 9.72E-06 | C3; CXCL11; CXCL8; CCL20; CXCL1; CXCL13 |
| R-HSA-5660668 | CLEC7A/inflammasome pathway | 1.18E-06 | 1.30E-05 | IL1B |