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19 January 2021: Database Analysis

Bioinformatics Analysis of Differentially Expressed Genes and Protein–Protein Interaction Networks Associated with Functional Pathways in Ulcerative Colitis

Feng Cao AE* , Yun-Sheng Cheng E* , Liang Yu D , Yan-Yan Xu AG* , Yong Wang A*

DOI: 10.12659/MSM.927917

Med Sci Monit 2021; 27:e927917

Table 1 The Gene Ontology enrichment analysis of the top 3 hub genes.

GenesBiological processCellular componentMolecular function
CXCL8GO: 0001525 angiogenesis;GO: 0002237 response to molecule of bacterial origin;GO: 0006935 chemotaxis;GO: 0006952 defense response;GO: 0006954 inflammatory response;GO: 0006955 immune response;GO: 0007050 cell cycle arrest;GO: 0007165 signal transduction;GO: 0007186 G protein-coupled receptor signaling pathway;GO: 0008285 negative regulation of cell proliferationGO: i0005576 extracellular region;GO: 0005615 extracellular spaceGO: 0005125 cytokine activity;GO: 0005153 interleukin-8 receptor binding;GO: 0005515 protein binding;GO: 0008009 chemokine activity
CXCL1GO: 0006935 chemotaxis;GO: 0006952 defense response;GO: 0006954 inflammatory response;GO: 0006955 immune response;GO: 0007165 signal transduction;GO: 0007186 G protein-coupled receptor signaling pathway;GO: 0007399 nervous system development;GO: 0008285 negative regulation of cell proliferation;GO: 0019221 cytokine-mediated signaling pathway;GO: 0030036 actin cytoskeleton organization;GO: 0005576 extracellular region;GO: 0005615 extracellular space;GO: 0035580 specific granule lumen;GO: 1904724 tertiary granule lumenGO: 0005102 signaling receptor binding;GO: 0005125 cytokine activity;GO: 0008009 chemokine activity;GO: 0008047 enzyme activator activity;GO: 0008083 growth factor activity
IL1BGO: 0000165 MAPK cascade;GO: 0000187 activation of MAPK activity;GO: 0001660 fever generation;GO: 0001934 positive regulation of protein phosphorylation;GO: 0002711 positive regulation of T cell mediated immunity;GO: 0006915 apoptotic process;GO: 0006954 inflammatory response;GO: 0006955 immune response;GO: 0007165 signal transduction;GO: 0007267 cell-cell signalingGO: 0005576 extracellular region;GO: 0005615 extracellular space;GO: 0005737 cytoplasm;GO: 0005764 lysosome;GO: 0005776 autophagosome; GO: 0005829 cytosol;GO: 0030141 secretory granule;GO: 0031410 cytoplasmic vesicle;GO: 0031982 vesicleGO: 0005125 cytokine activity;GO: 0005149 interleukin-1 receptor binding;GO: 0005178 integrin binding;GO: 0005515 protein binding;GO: 0019904 protein domain specific binding

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750