14 November 2020: Clinical Research
Association of Carotid Plaque and Serum Lipoprotein-Associated Phospholipase A2 (LP-PLA2) with Postoperative Delirium in Geriatric Patients Undergoing Hip Replacement: A Prospective Cohort Study
Tiantian Wan 1ABCDEF , Penghui Wei 2ABCDE , Yong Yao 3ABCDE , Hui Liu 4BCE , Jianjun Li 2ABCDEFG*DOI: 10.12659/MSM.927763
Med Sci Monit 2020; 26:e927763
Table 1 Demographic and clinical characteristics and incidence of postoperative delirium and perioperative serum LP-PLA2 levels in the CP group and non-CP group.
| Variable | CP group (n=36) | Non-CP group (n=26) | P value | |
|---|---|---|---|---|
| Age, years | 76.75±8.25 | 75.62±7.28 | 0.577 | |
| Sex, male (%) | 10 (27.78%) | 8 (30.77%) | 0.798 | |
| BMI, kg/m | 24.14±3.06 | 23.27±3.47 | 0.300 | |
| Education-level, n (%) | 0–5years | 17 (47.20%) | 10 (38.50%) | 0.442 |
| 6–9years | 13 (36.10%) | 10 (38.50%) | ||
| >9years | 6 (16.70%) | 6 (23.10%) | ||
| ASA score, n (%) | I | 0 | 0 | 0.104 |
| II | 33 (91.7%) | 20 (76.9%) | ||
| III | 3 (8.3%) | 6 (23.1%) | ||
| MMSE (point) | 26.39±1.36 | 26.85±1.46 | 0.113 | |
| Coronary artery disease, n (%) | 11 (30.6%) | 4 (15.4%) | 0.169 | |
| Diabetes, n (%) | 8 (22%) | 8 (31%) | 0.861 | |
| Hypertension, n (%) | No | 17 (47.2%) | 8 (30.8%) | 0.976 |
| Level 1 | 4 (11.1%) | 10 (38.5%) | ||
| Level 2 | 11 (30.6%) | 8 (30.8%) | ||
| Level 3 | 4 (11.1%) | 0 | ||
| Stains, n (%) | 3 (8.30%) | 4 (15.38%) | 0.387 | |
| Arrhythmia, n (%) | 2 (5.60%) | 4 (15.40%) | 0.196 | |
| Smoking habit, n (%) | 5 (13.90%) | 1 (3.85%) | 0.187 | |
| NEUT, % | 57.97±15.92 | 57.21±10.54 | 0.832 | |
| CRP, mg/L | 10.28±8.47 | 8.97±11.06 | 0.636 | |
| HDL, mmol/L | 1.24±0.24 | 1.26±0.26 | 0.792 | |
| LDL, mmol/L | 7.24±28.86 | 2.19±0.49 | 0.397 | |
| TC, mmol/L | 5.16±0.91 | 4.86±0.81 | 0.389 | |
| TGs, mmol/L | 1.67±1.55 | 1.10±0.27 | 0.113 | |
| BUN, mmol/L | 5.69±1.62 | 5.46±1.52 | 0.572 | |
| Duration of anesthesia, min | 73.61±18.05 | 84.00±11.55 | 0.158 | |
| bleeding volume, ml | 237.50±147.05 | 232.31±88.91 | 0.873 | |
| bone cement,% | 55.66% | 65.38% | 0.436 | |
| length of stay, day | 13.87±4.77 | 15.35±5.27 | 0.307 | |
| VAS score | Postoperative 1 day | 3.00±0.93 | 2.69±0.88 | 0.193 |
| Postoperative 2 day | 2.78±0.72 | 2.46±0.97 | 0.141 | |
| POD of postoperative day 1 | 3 (8.3%) | 1 (3.8%) | 0.757 | |
| POD of postoperative day 2 | 10 (27.8%) | 1 (3.8%) | 0.014* | |
| POD of postoperative day 3 | 1 (2.8%) | 0 | 0.392 | |
| POD of postoperative day 1~3 | 14 (38.9%) | 2 (7.69%) | 0.005* | |
| LP-PLA2 of T0, ng/ml | 372.80±29.00 | 356.74±43.98 | 0.088 | |
| LP-PLA2 of T1, ng/ml | 369.82±25.04 | 351.36±30.36 | 0.011 | |
| LP-PLA2 of T2, ng/ml | 381.32±33.08 | 346.54±30.21 | 0.000 | |
| BMI – body mass index; ASA – American Society of Anesthesiologists; MMSE – mini-mental state examination; NEUT – neutrophil; CRP – C-reactive protein; HDL – high-density lipoprotein; LDL – low-density lipoprotein; TC – total cholesterol; TGs – triglycerides; BUN – blood urea nitrogen; VAS – visual algetic mimic scale. Compared with non-CP group, * P Preoperatively (T0), at the end of surgery (T1), postoperative day 2 (T2). | ||||