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21 January 2021: Database Analysis

Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study

Dandan Zhou 1ABCEF** , Baohua Zhu 2ABCDF* , Jie Jiang 2DEF , Guangquan Zhou 3CEF , Suming Zhou 4ADEF*

DOI: 10.12659/MSM.927716

Med Sci Monit 2021; 27:e927716

Table 9 Outcomes of patients in the low-, moderate-, and high-dose dopamine groups.

VariableDopamine dose groupP value
Low (<5 μg/kg/min)Moderate (5–15 μg/kg/min)High (>15 μg/kg/min)
(n=93)(n=293)(n=52)
Mortality rates (%)
 7-day8 (8.6%)28 (9.6%)9 (17.3%)0.195
 28-day19 (20.4%)71 (24.2%)17 (32.7%)0.245
 90-day31 (33.3%)109 (37.2%)21 (40.4%)0.698
Mechanical ventilation (%)50 (53.8%)172 (58.7%)37 (71.2%)0.119
Vent durations (h)56 (2.25, 206)140 (38.67, 285.5)32.32 (0, 143.8)
New RRT (%)1 (1.1%)3 (1%)0 (0%)1*
AKI (%)26 (28%)57 (19.5%)8 (10.8%)0.123
Increased heart rate (bpm)33.45±25.9332.53±22.1535.04±23.420.356
Emerging arrhythmias (%)47 (50.5%)146 (49.8%)23 (44.2%)0.733
Emerging malignant arrhythmias (%)3 (3.2%)15 (5.1%)4 (7.7%)0.534
Reduced hemoglobin (g/dL)1.36±1.281.73±1.551.78±1.410.259
Platelet decline (k/μL)64.06±65.270.14±69.181.65±71.540.986
* Using Fisher’s exact test.
AKI – acute kidney injury; RRT – renal replacement therapy.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750