Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study

21 January 2021: Database Analysis

Dandan Zhou ^1ABCEF** , Baohua Zhu ^2ABCDF* , Jie Jiang ^2DEF , Guangquan Zhou ^3CEF , Suming Zhou ^4ADEF*

DOI: 10.12659/MSM.927716

Med Sci Monit 2021; 27:e927716

Table 8 Demographic characteristics and clinical basis data for patients in the low-, moderate-, and high-dose dopamine groups.

Variables	Dopamine dose group			P value
	Low (<5 μg/kg/min)	Moderate (5–15 μg/kg/min)	High (>15 μg/kg/min)
	(n=93)	(n=293)	(n=52)

Age (years, mean±SD)	74.93±12.29	74.88±12.28	72.27±12.29	0.982
Sex (% Male)	50 (53.8%)	133 (45.4%)	25 (48.1%)	0.379
Weight (kg)	82.61±29.27	81.11±25.30	79.08±22.17	0.487
Temperature	36 (35.58, 36.49)	36 (35.56, 37.3)	35.8 (35.3, 37.4)	0.397
Heart rate (bpm)	82.33±18.91	82.44±18.16	83.69±17.92	0.688
CHF	40 (43%)	145 (49.5%)	27 (51.9%)	0.480
Preexisting HF	92 (98.9%)	289 (98.6%)	51 (98.1%)	0.829^*
Dobutamine	10 (10.8%)	29 (9.9%)	8 (15.4%)	0.500

Lactate (mmol/L)	2.42±1.86	2.14±1.76	1.99±1.36	0.333
Bilirubin (mg/dL)	0.86±1.57	0.94±2.24	1.05±2.03	0.776
sCR (μmol/L)	1.78±1.23	2.11±1.63	2.08±1.58	0.156
BUN (mmol/L)	37.45±24.07	43.55±27.77	43.86±24.72	0.334
Platelets (k/μL)	240.33±123.95	239.49±105.28	252.46±110.86	0.290
Hemoglobin (g/dL)	10.32±1.76	10.61±1.95	10.69±1.88	0.287

SOFA	5 (4,7)	6 (5,8)	7 (6,9)
APS-III	49 (39.5, 58.5)	54 (43, 65.5)	55.5 (49, 69.5)	0.001
SAPS II	40 (32, 48)	45 (37, 52)	48 (39.25, 58.75)
GCS	14 (10, 15)	13 (9, 15)	11 (7.25, 14)	0.012
PaO/FiO	231 (166.8, 329.5)	193.7 (130.7, 289.4)	192.5 (134, 302)	0.046
APS-III – Acute Physiology Score III; BUN – blood urea nitrogen; CHF – congestive heartfFailure; HR – heart rate; sCR – serum creatinine; SAPS II – Simplified Acute Physiology Score II; SD – standard deviation, SOFA – Sequential Organ Failure Assessment. ^* Using Fisher’s exact test.