Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study

21 January 2021: Database Analysis

Dandan Zhou ^1ABCEF** , Baohua Zhu ^2ABCDF* , Jie Jiang ^2DEF , Guangquan Zhou ^3CEF , Suming Zhou ^4ADEF*

DOI: 10.12659/MSM.927716

Med Sci Monit 2021; 27:e927716

Table 5 Associations with 5-year mortality in patients with sepsis and heart failure in the NE, NE+VAS, and dopamine groups.

	Unadjusted (n=1864)	P value	Adjusted (n=1864)	P value
	Composite endpoint HR (95% CI)	P value	HR (95% CI)	P value
Sex (Male)	1.003 (0.899, 1.120)	0.952
Age	1.019 (1.014–1.023)		1.019 (1.015–1.024)
Weight (kg)	0.995 (0.993–0.998)		0.997 (0.995–0.999)	0.028
Race (White)	1.009 (0.892–1.143)	0.883
Group (NE reference)
NE+VAS	1.585 (1.379–1.821)		1.466 (1.266–1.697)
Dopamine	1.056 (0.922–1.209)	0.432	1.053 (0.915–1.212)	0.474
SOFA	1.060 (1.042–1.079)		0.983 (0.959–1.009)	0.199
APS-III	1.016 (1.013–1.018)		1.010 (1.008–1.013)
GCS	0.981 (0.968–0.994)	0.004	0.991 (0.976–1.007)	0.266
Lactate (mmol/L)	1.068 (1.039–1.097)		1.017 (0.985–1.049)	0.300
PaO/FiO	1.000 (0.999–1.000)	0.097	1.000 (0.999–1.000)	0.076
Bilirubin	1.048 (1.034–1.063)		1.036 (1.021–1.052)
Platelets (k/μL)	1.000 (0.999–1.000)	0.163
sCr (μmol/L)	1.067 (1.036–1.099)		1.016 (0.972–1.062)	0.478
BUN	1.008 (1.007–1.010)		1.004 (1.001–1.007)	0.002
Hemoglobin	0.939 (0.911–0.968)		0.963 (0.933–0.993)	0.017
Heart rate (bpm)	1.005 (1.002–1.008)	0.001	1.005 (1.002–1.008)	0.002
CHF	1.515 (1.331–1.724)		1.418 (1.235–1.629)
Preexisting HF	0.887 (0.625–1.260)	0.505
Temperature	0.904 (0.870–0.940)		0.948 (0.912–0.985)	0.011
Dobutamine	1.447 (1.206–1.736)		1.458 (1.212–1.754)
APS-III – Acute Physiology Score III; BUN – blood urea nitrogen; CHF – congestive heart failure; GCS – Glasgow Coma Score; HF – heart failure; NE – norepinephrine plus vasopressin; sCr – serum creatinine; SOFA – Sequential Organ Failure Assessment; VAS – vasopressin.