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21 January 2021: Database Analysis

Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study

Dandan Zhou 1ABCEF** , Baohua Zhu 2ABCDF* , Jie Jiang 2DEF , Guangquan Zhou 3CEF , Suming Zhou 4ADEF*

DOI: 10.12659/MSM.927716

Med Sci Monit 2021; 27:e927716

Table 2 Outcomes in the patients.

VariableGroupP value
NE (n=1055)NE+VAS (n=371)Dopamine (n=438)
Mortality rate (%)
 7-d105 (10%)85 (22.9%)45 (10.3%)
 28-d284 (26.9%)189 (50.9%)107 (24.4%)
 90-d409 (38.8%)232 (62.5%)161 (36.8%)
ICU LOS (h)231.76±235.84347.52±312.16171.52±171.93*
Hos LOS (d)15.58±12.917.44±14.5313.07±10.62*
Mechanical ventilation (%)758 (71.8%)336 (90.6%)259 (59.1%)
Vent durations (h)47.77 (0, 173.8)148.3 (44,307)12.38 (0, 87.17)
New RRT (%)21 (2%)50 (41.5%)4 (0.9%)**
AKI (%)257 (24.4%)154 (35.6%)91 (20.8%)
Increased heart rate (bpm)37.99±26.5245.84±29.3932.02±23.11
Emerging arrhythmias (%)392 (37.2%)164 (44.2%)216 (49.3%)
Emerging malignant arrhythmias (%)46 (4.4%)42 (11.3%)22 (5%)
Reduced hemoglobin (g/dL)1.69±1.502.08±1.731.66±1.52
Platelet decline (k/μL)71.48±80.32100.09±97.5170.21±76.81
Data are presented as n (%), mean±SD, or median and interquartile range. values are comparisons between the NE, VAS, NE+VAS, and dopamine groups.
* Using the Welch’s test;
** Using Fisher’s exact test.
AKI – acute kidney injury; Hos LOS –time from transfer to ICU to discharge; ICU LOS – Intensive Care Unit length of stay; NE – norepinephrine; RRT – renal replacement therapy; SD – standard deviation; VAS – vasopressin; Vent durations – mechanical ventilation time.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750