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21 January 2021: Database Analysis

Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study

Dandan Zhou 1ABCEF** , Baohua Zhu 2ABCDF* , Jie Jiang 2DEF , Guangquan Zhou 3CEF , Suming Zhou 4ADEF*

DOI: 10.12659/MSM.927716

Med Sci Monit 2021; 27:e927716

Table 1 Demographic characteristics and clinical baseline data for the patients.

VariablesNE group (n=1055)NE+VAS group (n=371)Dopamine group (n=438)P value
Age (y, mean±SD)72.54±13.669.06±14.1174.58±12.28*
Sex (% Male)555 (52.6%)217 (58.5%)208 (47.5%)0.008
Weight (kg)81.75±25.1286.3±29.2781.18±25.820.016*
Ethnicity (% White)785 (74.4%)275 (74.1%)296 (67.6%)0.021
CHF852 (80.8%)282 (76%)212 (48.4%)
Preexisting HF1026 (97.3%)362 (97.6%)432 (98.6%)0.278
Valvular disease168 (15.9%)65 (17.5%)54 (12.3%)0.097
Peripheral vascular137 (13%)49 (13.2%)60 (13.7%)0.934
Hypertension236 (22.4%)82 (22.1%)71 (16.2%)0.023
Chronic pulmonary280 (26.5%)104 (28%)121 (27.6%)0.822
Neurological151 (14.3%)34 (9.2%)39 (8.9%)0.002
Diabetes376 (35.6%)136 (36.7%)143 (32.6%)0.431
Hypothyroidism167 (15.8%)36 (9.7%)57 (13%)0.011
Chronic kidney disease306 (29%)107 (28.8%)103 (23.5%)0.083
Liver disease67 (6.4%)45 (12.1%)19 (4.3%)
Lymphoma24 (2.3%)9 (2.4%)7 (1.6%)0.654
Tumor31 (2.9%)13 (3.5%)10 (2.3%)0.583
Rheumatoid arthritis33 (3.1%)14 (3.8%)11 (2.5%)0.588
Coagulopathy241 (22.8%)129 (34.8%)56 (12.8%)
Temperature (°C)36.1 (35.56, 37.5)36.06 (35.4, 37.5)36 (35.56, 37.13)0.047
Heart rate (bpm)87.29±18.4491.68±21.3982.56±18.26*
Dobutamine66 (6.3%)51 (13.7%)47 (10.7%)
Bacteria704 (66.7%)254 (68.5%)299 (68.3%)0.758
Fungi192 (18.2%)70 (18.9%)61 (13.9%)0.095
Virus10 (0.9%)0 (0%)2 (0.5%)0.147**
Lactate (mmol/L)2.09±1.4983.19±2.912.18±1.74*
Bilirubin (mg/dL)1.36±3.592.24±4.440.93±2.08*
sCR (μmol/L)1.81±1.582.01±1.602.04±1.550.015*
BUN (mmol/L)37.18±25.1238.83±24.9142.29±26.740.003*
Platelets (k/uL)226.91±127.06211.99±127.92241.21±109.970.002*
Hemoglobin (g/dL)10.14±1.8210.18±1.8510.56±1.90*
SOFA7 (5, 9)9 (6, 11)6 (4, 8)
APS-III55 (43, 68)65 (50, 86)52.5 (42, 65)
SAPS II46 (38, 54)51 (41, 61)44 (36, 53)
GCS11 (8, 14)10 (6, 14)14 (9, 15)
PaO/FiO217 (140, 323)200 (119, 298.3)202.77 (136.65, 301.36)0.019
Data are presented as n (%), mean±SD, or median and interquartile range. values are comparisons between the NE, NE+VAS, and dopamine groups.
* Using Welch’s test;
** Using Fisher’s exact test.
APS-III – Acute Physiology Score III; CHF – congestive heart failure; GCS – Glasgow Coma Scale, HF – heart failure; HR – heart rate; NE – norepinephrine; Preexisting HF – preexisting heart failure; SAPS II – Simplified Acute Physiology Score II; sCR – serum creatinine; SD – standard deviation; SOFA – Sequential Organ Failure Assessment; VAS – vasopressin.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750