21 January 2021>: Database Analysis
Norepinephrine, Dopamine, and Vasopressin in Patients with Sepsis and Preexisting or Acute Heart Failure: A Retrospective Cohort Study
Dandan Zhou 1ABCEF** , Baohua Zhu 2ABCDF* , Jie Jiang 2DEF , Guangquan Zhou 3CEF , Suming Zhou 4ADEF*DOI: 10.12659/MSM.927716
Med Sci Monit 2021; 27:e927716
Table 1 Demographic characteristics and clinical baseline data for the patients.
Variables | NE group (n=1055) | NE+VAS group (n=371) | Dopamine group (n=438) | P value |
---|---|---|---|---|
Age (y, mean±SD) | 72.54±13.6 | 69.06±14.11 | 74.58±12.28 | * |
Sex (% Male) | 555 (52.6%) | 217 (58.5%) | 208 (47.5%) | 0.008 |
Weight (kg) | 81.75±25.12 | 86.3±29.27 | 81.18±25.82 | 0.016* |
Ethnicity (% White) | 785 (74.4%) | 275 (74.1%) | 296 (67.6%) | 0.021 |
CHF | 852 (80.8%) | 282 (76%) | 212 (48.4%) | |
Preexisting HF | 1026 (97.3%) | 362 (97.6%) | 432 (98.6%) | 0.278 |
Valvular disease | 168 (15.9%) | 65 (17.5%) | 54 (12.3%) | 0.097 |
Peripheral vascular | 137 (13%) | 49 (13.2%) | 60 (13.7%) | 0.934 |
Hypertension | 236 (22.4%) | 82 (22.1%) | 71 (16.2%) | 0.023 |
Chronic pulmonary | 280 (26.5%) | 104 (28%) | 121 (27.6%) | 0.822 |
Neurological | 151 (14.3%) | 34 (9.2%) | 39 (8.9%) | 0.002 |
Diabetes | 376 (35.6%) | 136 (36.7%) | 143 (32.6%) | 0.431 |
Hypothyroidism | 167 (15.8%) | 36 (9.7%) | 57 (13%) | 0.011 |
Chronic kidney disease | 306 (29%) | 107 (28.8%) | 103 (23.5%) | 0.083 |
Liver disease | 67 (6.4%) | 45 (12.1%) | 19 (4.3%) | |
Lymphoma | 24 (2.3%) | 9 (2.4%) | 7 (1.6%) | 0.654 |
Tumor | 31 (2.9%) | 13 (3.5%) | 10 (2.3%) | 0.583 |
Rheumatoid arthritis | 33 (3.1%) | 14 (3.8%) | 11 (2.5%) | 0.588 |
Coagulopathy | 241 (22.8%) | 129 (34.8%) | 56 (12.8%) | |
Temperature (°C) | 36.1 (35.56, 37.5) | 36.06 (35.4, 37.5) | 36 (35.56, 37.13) | 0.047 |
Heart rate (bpm) | 87.29±18.44 | 91.68±21.39 | 82.56±18.26 | * |
Dobutamine | 66 (6.3%) | 51 (13.7%) | 47 (10.7%) | |
Bacteria | 704 (66.7%) | 254 (68.5%) | 299 (68.3%) | 0.758 |
Fungi | 192 (18.2%) | 70 (18.9%) | 61 (13.9%) | 0.095 |
Virus | 10 (0.9%) | 0 (0%) | 2 (0.5%) | 0.147** |
Lactate (mmol/L) | 2.09±1.498 | 3.19±2.91 | 2.18±1.74 | * |
Bilirubin (mg/dL) | 1.36±3.59 | 2.24±4.44 | 0.93±2.08 | * |
sCR (μmol/L) | 1.81±1.58 | 2.01±1.60 | 2.04±1.55 | 0.015* |
BUN (mmol/L) | 37.18±25.12 | 38.83±24.91 | 42.29±26.74 | 0.003* |
Platelets (k/uL) | 226.91±127.06 | 211.99±127.92 | 241.21±109.97 | 0.002* |
Hemoglobin (g/dL) | 10.14±1.82 | 10.18±1.85 | 10.56±1.90 | * |
SOFA | 7 (5, 9) | 9 (6, 11) | 6 (4, 8) | |
APS-III | 55 (43, 68) | 65 (50, 86) | 52.5 (42, 65) | |
SAPS II | 46 (38, 54) | 51 (41, 61) | 44 (36, 53) | |
GCS | 11 (8, 14) | 10 (6, 14) | 14 (9, 15) | |
PaO/FiO | 217 (140, 323) | 200 (119, 298.3) | 202.77 (136.65, 301.36) | 0.019 |
Data are presented as n (%), mean±SD, or median and interquartile range. values are comparisons between the NE, NE+VAS, and dopamine groups. * Using Welch’s test; ** Using Fisher’s exact test. APS-III – Acute Physiology Score III; CHF – congestive heart failure; GCS – Glasgow Coma Scale, HF – heart failure; HR – heart rate; NE – norepinephrine; Preexisting HF – preexisting heart failure; SAPS II – Simplified Acute Physiology Score II; sCR – serum creatinine; SD – standard deviation; SOFA – Sequential Organ Failure Assessment; VAS – vasopressin. |