26 October 2020: Clinical Research
A Chinese Retrospective Multicenter Study of First-Line Chemotherapy for Advanced Pancreatic Cancer
Hanzhi Cui 12BCDEF* , Jingzhi Guan 2D* , Guochao Deng 1B , Jiajia Yuan 3B , Changjie Lou 4B , Wen Zhang 5B , Aiping Zhou 5BD , Yanqiao Zhang 4D , Jun Zhou 3D , Guanghai Dai 6ADG*DOI: 10.12659/MSM.927654
Med Sci Monit 2020; 26:e927654
Table 2 Rates of treatment response in patients in the trial.
| Event | AS | AG | FOLFIRINOX | P value | ||||
|---|---|---|---|---|---|---|---|---|
| Any grade (%) | Grade 3/4(%) | Any grade (%) | Grade 3/4(%) | Any grade (%) | Grade 3/4 (%) | Any grade (%) | Grade 3/4 (%) | |
| Myelosuppression | 151 (68.3) | 54 (24.4) | 61 (63.2) | 15 (19.7) | 9 (81.8) | 3 (27.3) | 0.44 | 0.619 |
| Neurotoxicity | 97 (43.9) | 7 (3.2) | 15 (19.7) | 2 (2.6) | 2 (18.2) | 0 | 0.006 | |
| Diarrhea | 26 (12.3) | 5 (2.3) | 10 (13.2) | 0 | 4 (36.4) | 2 (18.2) | 0.002 | |
| Nausea and vomiting | 114 (51.6) | 4 (1.8) | 35 (46.1) | 1 (1.3) | 5 (45.5) | 1 (9.1) | 0.664 | |
| Liver dysfunction | 33 (14.9) | 1 (0.5) | 10 (13.2) | 1 (1.3) | 4 (36.4) | 0 | 0.502 | |
| Alopecia | 50 (22.6) | 2 (0.9) | 2 (2.6) | 0 | 0 | 0 | 0.005 | |
| Oral mucositis | 8 (3.6) | 3 (1.4) | 0 | 0 | 0 | 0 | 0.779 | |
| Rash | 11 (5) | 1 (0.5) | 1 (1.3) | 0 | 0 | 0 | 0.832 | |
| Total | 66 (29.9) | 19 (25) | 4 (36.4) | |||||