26 October 2020: Clinical Research
A Chinese Retrospective Multicenter Study of First-Line Chemotherapy for Advanced Pancreatic Cancer
Hanzhi Cui 12BCDEF* , Jingzhi Guan 2D* , Guochao Deng 1B , Jiajia Yuan 3B , Changjie Lou 4B , Wen Zhang 5B , Aiping Zhou 5BD , Yanqiao Zhang 4D , Jun Zhou 3D , Guanghai Dai 6ADG*DOI: 10.12659/MSM.927654
Med Sci Monit 2020; 26:e927654
Table 1 Baseline characteristics of the 322 patients in the trial.
| Characteristic | AS (n=232) | AG (n=79) | FOLFIRINOX (n=11) | Total (n=322) | P value | ||||
|---|---|---|---|---|---|---|---|---|---|
| No. | % | No. | % | No. | % | No. | % | ||
| 0.275 | |||||||||
| Male | 140 | 60.3 | 52 | 65.8 | 9 | 81.8 | 201 | 62.4 | |
| Female | 92 | 39.7 | 27 | 34.2 | 2 | 18.2 | 121 | 37.6 | |
| (range) | 59 (36–79) | 59 (37–74) | 56 (43–67) | 58.5 (36–79) | |||||
| 0.062 | |||||||||
| 0 | 160 | 69.0 | 42 | 53.2 | 6 | 54.5 | 208 | 64.6 | |
| 1 | 71 | 30.6 | 35 | 44.3 | 5 | 45.5 | 111 | 34.5 | |
| 2 | 1 | 0.4 | 2 | 2.5 | 0 | 0.0 | 3 | 0.9 | |
| 87 | 39.0 | 30 | 40.5 | 2 | 20.0 | 119 | 38.8 | ||
| Head | 37 | 16.6 | 10 | 13.5 | 1 | 10.0 | 48 | 15.6 | 0.309 |
| Body | 48 | 21.5 | 19 | 25.7 | 3 | 30.0 | 70 | 22.8 | 0.574 |
| Tail | 47 | 21.1 | 15 | 20.3 | 4 | 40.0 | 66 | 21.5 | 0.852 |
| Body+tail | 4 | 1.8 | 0 | 0.0 | 0 | 0.0 | 4 | 1.3 | 0.49 |
| 0.58 | |||||||||
| Poor | 82 | 58.6 | 28 | 54.9 | 2 | 28.6 | 112 | 56.6 | |
| Moderate | 56 | 40.0 | 22 | 43.1 | 5 | 71.4 | 83 | 41.9 | |
| High | 2 | 1.4 | 1 | 2.0 | 0 | 0.0 | 3 | 1.5 | |
| 0.393 | |||||||||
| 1 | 145 | 63.9 | 43 | 58.1 | 4 | 40.0 | 192 | 61.7 | |
| 2 | 43 | 18.9 | 18 | 24.3 | 4 | 40.0 | 65 | 20.9 | |
| ≥3 | 39 | 17.2 | 13 | 17.6 | 2 | 20.0 | 54 | 17.4 | |
| Liver | 160 | 69.0 | 53 | 67.1 | 5 | 45.5 | 218 | 67.7 | 0.263 |
| Lung | 21 | 9.1 | 7 | 8.9 | 2 | 18.2 | 30 | 9.3 | 0.588 |
| Bone | 13 | 5.6 | 6 | 7.6 | 0 | 0.0 | 19 | 5.9 | 0.567 |
| Lymph node | 119 | 51.3 | 35 | 44.3 | 5 | 45.5 | 159 | 49.4 | 0.543 |
| Adrenal gland | 10 | 4.3 | 2 | 2.5 | 1 | 9.1 | 13 | 4.0 | 0.54 |
| 0.376 | |||||||||
| Yes | 50 | 21.6 | 23 | 29.1 | 3 | 27.3 | 76 | 23.6 | |
| No | 182 | 78.4 | 56 | 70.9 | 8 | 72.7 | 246 | 76.4 | |
| 0.143 | |||||||||
| Normal | 87 | 40.0 | 39 | 52.7 | 4 | 36.4 | 130 | 42.9 | |
| Abnormal | 131 | 60.0 | 35 | 47.3 | 7 | 63.6 | 173 | 57.1 | |
| 0.508 | |||||||||
| Normal | 34 | 15.3 | 14 | 18.4 | 3 | 27.3 | 51 | 16.5 | |
| Abnormal | 188 | 84.7 | 62 | 81.6 | 8 | 72.7 | 258 | 83.5 | |
| 0.312 | |||||||||
| Normal | 44 | 23.2 | 14 | 27.5 | 4 | 44.4 | 62 | 24.8 | |
| Abnormal | 146 | 76.8 | 37 | 72.5 | 5 | 55.6 | 188 | 75.2 | |
| (range) | 6 (2–23) | 4 (2–12) | 6 (3–16) | 5 (2–23) | |||||
| 0.79 | |||||||||
| Yes | 44 | 19.0 | 15 | 19.0 | 3 | 27.3 | 62 | 19.3 | |
| No | 188 | 81.0 | 64 | 81.0 | 8 | 72.7 | 260 | 80.7 | |