Efficacy of 5-Aminolevulinic Acid (ALA)-Photodynamic Therapy (PDT) in Refractory Vulvar Lichen Sclerosus: Preliminary Results

07 January 2021: Clinical Research

Fenghua Zhang ^1ABCEF , Daoyun Li ^1BCD , Lijuan Shi ^1BC , Yijia Gu ^1C , Yun Xu ^1AEG* , Changping Wu ^234ACEG*

DOI: 10.12659/MSM.927406

Med Sci Monit 2021; 27:e927406

Table 2 The clinical manifestation, lesion size, and scores before treatment and at the 6-month follow-up.

No	Baseline				Lesions size at baseline			Total scores
No	Atrophy	Depigmentation	Hyperkertosis	Sclerosis	<30%	30–60%	>60%	Total scores
1	2	3	1	1	0	0	1.5	12.5
2	1	2	2	1	0	1	0	7
3	2	2	1	2	0	0	1.5	8.5
4	3	3	3	2	0	0	1.5	12.5
5	2	2	2	2	0	0	1.5	9.5
6	3	3	3	3	0	0	1.5	13.5
7	1	2	2	1	0	0	1.5	7.5
8	2	3	3	1	0	0	1.5	10.5
9	2	2	2	1	0	0	1.5	8.5
10	2	2	3	1	0	0	1.5	9.5
11	2	2	2	1	0	0	1.5	8.5
12	1	1	1	1	0	1	0	5
13	2	2	2	2	0	1	0	9
14	2	3	2	2	0	0	1.5	10.5
15	3	3	3	3	0	0	1.5	13.5
16	2	2	3	2	0	0	1.5	10.5
17	2	2	2	2	0	0	1.5	9.5
18	1	3	1	0	0	1	0	6
19	2	2	2	3	0	1	0	10
20	2	2	2	2	0.5	0	0	8.5
21	2	3	2	2	0	0	1.5	10.5
22	3	3	3	3	0	0	1.5	13.5
23	1	2	2	1	0	1	0	7
24	1	2	1	0	0.5	0	0	4.5
25	3	3	3	3	0	0	1.5	13.5
26	2	3	1	3	0.5	0	0	8.5
27	2	3	2	2	0	1	0	10
28	3	3	3	2	0	0	1.5	12.5
29	3	2	3	1	0	1	0	10
30	3	3	3	1	0	0	1.5	11.5



1	1	1	0	0	0.5	0	0	2.5
2	0	0	0	0	0.5	0	0	0.5
3	0	0	0	0	0.5	0	0	0.5
4	1	1	0	1	0.5	0	0	3.5
5	0	1	0	0	0	0	0	1
6	1	1	1	1	0.5	0	0	3.5
7	0	0	0	0	0	0	0	0
8	0	0	0	0	0	0	0	0
9	0	0	0	0	0.5	0	0	0.5
10	0	0	0	0	0	0	0	0
11	0	0	0	0	0	0	0	0
12	0	0	0	0	0	0	0	0
13	0	0	0	0	0	0	0	0
14	1	1	0	0	0.5	0	0	0.5
15	1	1	1	1	0.5	0	0	5.5
16	0	1	0	0	0	0	0	1
17	0	1	0	0	0.5	0	0	1.5
18	0	0	0	0	0.5	0	0	0.5
19	0	0	0	0	0	0	0	0
20	0	0	0	0	0	0	0	0
21	0	0	0	0	0	0	0	0
22	0	1	1	0	0.5	0	0	2.5
23	0	0	0	0	0	0	0	0
24	0	0	0	0	0	0	0	0
25	1	2	1	1	0.5	0	0	5.5
26	0	0	0	0	0	0	0	0
27	1	1	0	0	0.5	0	0	3
28	0	1	1	0	0.5	0	0	2.5
29	0	0	0	0	0	0	0	0
30	0	0	0	0	0	0	0	0

The comparison of total scores before and after treatment underwent by paired student’s t test.