The Clinical Significance of Dickkopf Wnt Signaling Pathway Inhibitor Gene Family in Head and Neck Squamous Cell Carcinoma

26 November 2020: Database Analysis

Yuan Hu ^ABCEF , Muyuan Liu ^CD , Shaowei Xu ^BD , Shaokun Li ^EF , Mingfeng Yang ^G , Tian Su ^B , Zihong Yuan ^C , Hanwei Peng ^AD*

DOI: 10.12659/MSM.927368

Med Sci Monit 2020; 26:e927368

Table 1 Expression of DKKs at the transcription level in HNC and normal tissues (Oncomine).

	Types of HNC vs. NC	Fold change	P value	t Test	Reference
DKK1	Oral cavity squamous cell carcinoma	3.734	2.31E-14	9.378	Peng et al. []¹⁵
DKK1	Oral cavity squamous cell carcinoma	1.666	0.005	2.872	Toruner et al. []¹⁶
DKK2	Head and neck squamous cell carcinoma	−2.451	1.34E-06	−5.311	Ginos et al. []¹⁷
	Oral cavity squamous cell carcinoma	−1.883	1.73E-10	−8.124	Peng et al. []¹⁵
	Floor of the mouth carcinoma	−2.963	1.86E-04	−4.111	Pyeon et al. []¹⁸
	Tongue carcinoma	−2.577	4.88E-04	−3.743	Pyeon et al. []¹⁸
DKK3	Nasopharyngeal carcinoma	2.196	1.96E-05	4.777	Sengupta et al. []¹⁹
DKK4	Head and neck squamous cell carcinoma	−8.783	1.66E-10	−8.783	Ginos et al. []¹⁷
DKK4	Oral cavity squamous cell carcinoma	−2.217	2.33E-11	−9.586	Peng et al. []¹⁵
HNC – head and neck cancer; DKK – Dickkopf Wnt signaling pathway inhibitor; NC – normal control.