Integrated Bioinformatics Analysis of Hub Genes and Pathways Associated with a Compression Model of Spinal Cord Injury in Rats

05 November 2020: Lab/In Vitro Research

Chang Jiang ^BCE* , Zheng Li ^BCE* , Zhaoyi Wu ^DEF* , Yun Liang ^CD , Lixia Jin ^BD , Yuanwu Cao ^CG , Shengcheng Wan ^DG , Zixian Chen ^AG*

DOI: 10.12659/MSM.927107

Med Sci Monit 2020; 26:e927107

Table 2 Overview of 10 modules with their top 3 GO-BP terms.

Module	N	Term	Count	%	FDR
Turquoise	679	Chemical synaptic transmission	41	6.0	8.0E-23
		Sensory perception of pain	25	3.7	5.9E-17
		Neurotransmitter secretion	18	2.7	1.6E-16
Blue	444	Inflammatory response	26	5.9	1.2E-08
		Innate immune response	22	5.0	3.8E-07
		Phagocytosis, engulfment	8	1.8	9.7E-06
Brown	151	Cell division	24	15.9	1.0E-21
		Chromosome segregation	17	11.3	4.7E-20
		Mitotic nuclear division	16	10.6	4.9E-14
Yellow	79	rRNA processing	5	6.3	1.5E-04
		tRNA methylation	3	3.8	4.4E-03
		Ribosomal large subunit assembly	3	3.8	6.6E-03
Green	63	Collagen fibril organization	6	9.5	1.7E-07
		Blood vessel development	6	9.5	2.9E-06
		Extracellular matrix organization	6	9.5	1.4E-05
Red	30	Innate immune response	4	13.3	9.0E-03
		Cellular calcium ion homeostasis	3	10.0	1.1E-02
		High-density lipoprotein particle remodeling	2	6.7	2.0E-02
Pink	22	Receptor-mediated endocytosis	2	9.1	1.0E-01
		Aging	2	9.1	2.9E-01
		Apoptotic process	2	9.1	3.3E-01
Black	22	Neuron projection development	3	13.6	2.5E-03
		Protein localization to synapse	2	9.1	1.2E-02
		Signal transduction	4	18.2	1.8E-02
Magenta	19	Regulation of norepinephrine secretion	2	10.5	8.2E-03
		Adenosine receptor signaling pathway	2	10.5	1.0E-02
		Toll-like receptor signaling pathway	2	10.5	1.9E-02
N – number of genes involved in the given module; Count – number of genes involved in the given term; % – percentage of involved genes/total genes; FDR – adjusted values obtained applying the Benjamini-Hochberg method.