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16 October 2020: Clinical Research

Single Large Nodule (>5 cm) Prognosis in Hepatocellular Carcinoma: Kinship with Barcelona Clinic Liver Cancer (BCLC) Stage A or B?

Li Wan 12BCDE , Ding-Hui Dong 1ABCDE , Xiao-Ning Wu 1BCD , Hong-Fan Ding 1BCD , Qiang Lu 1BCD , Yong Tian 2BC , Xu-Feng Zhang 1ABCDEFG* , Wenzhi Li 13ADE*

DOI: 10.12659/MSM.926797

Med Sci Monit 2020; 26:e926797

Table 1 Characteristics of the patients with hepatocellular carcinoma in BCLC stages A1, A2, and B.

VariablesBCLC stages A1 (n=455)BCLC stage A2 (n=188)BCLC stage B (n=362)
Male sex366 (80.4%)154 (81.9%)292 (80.7%)
Age (years)55 (24–82)54 (22–82)55 (13–87)
History of cigarette smoking188 (41.3%)87 (46.3%)151 (41.7%)
History of alcohol abuse145 (31.9%)65 (34.6%)113 (31.2%)
Diabetes# 42 (9.2%)22 (11.7%)18 (5.0%)
HBV positivity338 (74.2%)133 (70.7%)249 (68.8%)
HCV positivity34 (7.5%)7 (3.7%)16 (4.4%)
Liver cirrhosis314 (69.0%)121 (64.4%)229 (63.3%)
Child-Pugh class B# 31 (6.8%)19 (10.1%)15 (4.1%)
AFP >200 ng/ml222 (48.8%)109 (58.0%)186 (51.4%)
Primary treatments
 Surgical resection155 (34.1%)49 (26.1%)130 (35.9%)
 Radiofrequency ablation* 129 (28.4%)32 (17.0%)43 (11.9%)
 TACE* 148 (32.5%)86 (45.7%)159 (43.9%)
 Supportive treatments* 23 (5.1%)21 (11.1%)30 (8.3%)
30-day mortality17 (3.7%)8 (4.3%)10 (2.8%)
90-day mortality28 (6.2%)14 (7.4%)30 (8.3%)
HCC – hepatocellular carcinoma; BCLC – Barcelona Clinic Liver Cancer; HBV – hepatitis B virus; HCV – hepatitis C virus; AFP – alpha-fetoprotein; TACE – transarterial chemoembolization.
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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750