01 December 2020>: Lab/In Vitro Research
Plasma Metabolomics Analysis Identifies Abnormal Energy, Lipid, and Amino Acid Metabolism in Abdominal Aortic Aneurysms
Yaming Guo 1EF* , Shuwei Wan 1EF* , Mingli Han 2C , Yubo Zhao 1B , Chuang Li 1B , Gaopo Cai 1C , Shuai Zhang 1D , Zhi Sun 3D , Xinhua Hu 4F , Hui Cao 1AG** , Zhen Li 1A*DOI: 10.12659/MSM.926766
Med Sci Monit 2020; 26:e926766
Table 2 Results of identification of differential metabolites.
Metabolites | Mode | VIP | P | FC | Class | Pathway |
---|---|---|---|---|---|---|
2-Oxoglutaric acid | ESI− | 1.58 | 0.33 | keto acids | TCA Cycle | |
Succinic acid | ESI− | 1.15 | 0.59 | Dicarboxylic acids | TCA Cycle | |
Citric acid | ESI− | 1.58 | 0.31 | Tricarboxylic acids | TCA Cycle | |
cis-Aconitic acid | ESI− | 1.48 | 0.01 | Tricarboxylic acids | TCA cycle | |
S1P | ESI+ | 1.38 | 0.52 | Phosphosphingolipids | Sphingolipid metabolism | |
Phytosphingosine | ESI+ | 3.35 | 0.64 | Amines | Sphingolipid metabolism | |
D-Sphingosine | ESI+ | 1.81 | 0.09 | Amines | Sphingolipid metabolism | |
D-carnitine | ESI+ | 2.50 | 1.40 | Organonitrogen | Lipid metabolism | |
Hexanoylcarnitine | ESI+ | 1.07 | 0.30 | Fatty acid esters | Lipid metabolism | |
L-Octanoylcarnitine | ESI+ | 2.36 | 0.35 | Fatty acid esters | Lipid metabolism | |
9-Decenoylcarnitine | ESI+ | 1.87 | 0.40 | Fatty acid esters | Lipid metabolism | |
Decanoylcarnitine | ESI+ | 1.63 | 0.41 | Fatty acid esters | Lipid metabolism | |
LysoPC (16: 0/0: 0) | ESI+ | 2.10 | 0.44 | Glycerophosphocholines | Lipid metabolism | |
PAF | ESI+ | 1.34 | 0.60 | Glycerophosphoethanolamines | Lipid metabolism | |
LysoPC (18: 2(9Z,12Z)/0: 0) | ESI+ | 3.30 | 0.01 | 0.85 | Glycerophosphocholines | Lipid metabolism |
L-Glutamic acid | ESI− | 1.3 | 0.53 | Amino acids, peptides, and analogues | D-Glutamine and D-glutamate metabolism | |
D-Glutamine | ESI− | 1.18 | 1.45 | Amino acids, peptides, and analogues | D-Glutamine and D-glutamate metabolism | |
L-Glutamine | ESI+ | 2.51 | 1.83 | Amino acids, peptides, and analogues | D-Glutamine and D-glutamate metabolism | |
Creatine | ESI+ | 2.23 | 1.55 | Amino acids, peptides, and analogues | Arginine and proline metabolism | |
L-Proline | ESI+ | 2.16 | 1.33 | Amino acids, peptides, and analogues | Arginine and proline metabolism | |
Arginine | ESI+ | 1.65 | 3.15 | Amino acids, peptides, and analogues | Arginine and proline metabolism | |
Creatinine | ESI+ | 2.53 | 1.66 | Amino acids, peptides, and analogues | Arginine and proline metabolism | |
Pyruvic acid | ESI− | 1.08 | 0.55 | Alpha-keto acids and derivatives | Alanine, aspartate and glutamate metabolism | |
D-Aspartic acid | ESI+ | 1.45 | 0.02 | Amino acids, peptides, and analogues | Alanine, aspartate and glutamate metabolism | |
DL-Serine | ESI+ | 1.27 | 1.33 | Amino acids, peptides, and analogues | Glycine, serine and threonine metabolism | |
Taurine | ESI− | 1.17 | 0.62 | Organosulfonic acids and derivatives | ABC transporters | |
Betaine | ESI+ | 3.35 | 1.22 | Amino acids, peptides, and analogues | ABC transporters | |
L-Phenylalanine | ESI+ | 5.68 | 1.37 | Amino acids, peptides, and analogues | ABC transporters | |
L-Isoleucine | ESI+ | 1.29 | 1.32 | Amino acids, peptides, and analogues | ABC transporters | |
Choline | ESI+ | 1.13 | 0.04 | 1.23 | Organonitrogen compounds | ABC transporters |
hypaphorine | ESI− | 1.27 | 0.39 | Amino acids, peptides, and analogues | / | |
L-Threonic acid | ESI− | 1.54 | 0.04 | Carbohydrates and carbohydrate conjugates | / | |
Glutaconic acid | ESI− | 1.48 | 0.05 | Dicarboxylic acids and derivatives | / | |
DL-Tryptophan | ESI− | 1.21 | 2.07 | Indolyl carboxylic acids and derivatives | / | |
[SP]Sphinganine-1-phosphate | ESI− | 1.23 | 0.53 | Phosphosphingolipids | / | |
Monobutyl phthalate | ESI+ | 1.33 | 0.31 | Benzoic acids and derivatives | / | |
Piperine | ESI+ | 1.55 | 0.10 | / | / | |
N-Phenylacetylglutamine | ESI+ | 1.48 | 4.00 | Amino acids, peptides, and analogues | / | |
5-Aminopentanamide | ESI+ | 3.34 | 0.18 | Amino acids, peptides, and analogues | / | |
Glu-asp | ESI+ | 2.63 | 0.01 | Amino acids, peptides, and analogues | / | |
allylcysteine | ESI+ | 1.00 | 0.40 | Amino acids, peptides, and analogues | / | |
Oleamide | ESI+ | 1.98 | 0.07 | Fatty amides | / | |
Caffeine | ESI+ | 1.42 | 0.14 | Purines and purine derivatives | / | |
Dihydrothymine | ESI+ | 1.26 | 2.61 | Pyrimidines and pyrimidine derivatives | / | |
Ubiquinone-1(CoQ1) | ESI+ | 1.41 | 0.40 | Quinone and hydroquinone lipids | / |