Overexpression of PKMYT1 Facilitates Tumor Development and Is Correlated with Poor Prognosis in Clear Cell Renal Cell Carcinoma

07 October 2020: Clinical Research

Overexpression of Facilitates Tumor Development and Is Correlated with Poor Prognosis in Clear Cell Renal Cell Carcinoma

Peng Chen ^1BCDEF* , Ziying Zhang ^12BCDEF* , Xiang Chen ^1ACDEG*

DOI: 10.12659/MSM.926755

Med Sci Monit 2020; 26:e926755

Table 1 Correlation between PKMYT1 mRNA levels and clinicopathological parameters in 530 patients with ccRCC from the TCGA database.

Variable	Groups	N	Low	High	χ2	P value
Age (years)	≤60	264	129	135	0.27136	0.6024
	>60	266	137	129
	NA
Sex	Male	344	164	180	2.2003	0.138
	Female	186	102	84
	NA
Race	White	459	226	233		0.4298^*
	Asian	8	4	4
	Black	56	33	23
	NA	7
Laterality	Right	280	148	132	1.5888	0.2075
	Left	249	117	132
	Bilateral	1
	NA
T classification	T1	271	149	122	22.122	P
	T2	69	44	25
	T3	179	72	107
	T4	11	1	10
	TX
	NA
N classification	N0	239	121	118	4.8908	0.027
	N1	16	3	13
	NX	275
	NA
M classification	M0	440	231	209	7.6072	0.0058
	M1	80	28	52
	MX	10
	NA
TNM stage	I	265	145	120	14.688	0.0021
	II	57	36	21
	III	123	55	68
	IV	82	29	53
	NA	3
Histologic grade	G1	14	11	3	19.3	0.0002
	G2	227	127	100
	G3	206	99	107
	G4	75	23	52
	NA	8
Tumor status	With tumor	138	54	84	8.4434	0.0037
	Tumor-free	358	194	164
	NA	34
Relapse	No	373	202	171	7.3991	0.0065
	Yes	157	64	93
	NA
Vital status	Dead	172	68	104	10.939	0.0009
	Alive	358	198	160
	NA
^* P value of Fisher’s exact test conducted on a small sample. mRNA – messenger RNA; ccRCC – clear cell renal cell carcinoma; TCGA – The Cancer Genome Atlas.