11 February 2021: Clinical Research
Risk Factors of Coronavirus Disease 2019-Related Mortality and Optimal Treatment Regimens: A Retrospective Study
Yuehong Wang 1BC* , Shuang Yao 2CDEF* , Xiaoling Liu 3BDEF* , Yinghao Cao 4ABCEF , Yaling Wang 5BF* , Mao Xie 6AEF*DOI: 10.12659/MSM.926751
Med Sci Monit 2021; 27:e926751
Table 3 The laboratory characteristics of the COVID-19 patients in the recovered and deceased groups.
| Totaln=97 (%) | Recoveredn=76 (%) | Deceasedn=21 (%) | P* | |
|---|---|---|---|---|
| WBC (G/L) | 7.10 (4.46–9.7) | 5.98 (4.28–9.06) | 9.70 (7.81–13.85) | 0.002 |
| Decreased | 8 (8.25) | 7 (9.21) | 1 (4.76) | 0.999 |
| Normal | 89 (91.75) | 69 (90.79) | 20 (95.24) | |
| LYM (G/L) | 0.77 (0.54–1.03) | 0.79 (0.55–1.04) | 0.56 (0.45–0.89) | 0.146 |
| Decreased | 76 (78.35) | 59 (77.63) | 17 (80.95) | 0.999 |
| Normal | 21 (21.65) | 17 (22.37) | 4 (19.05) | |
| NEU (G/L) | 6.04 (3.45–8.97) | 4.79 (3.28–7.965) | 8.92 (7.08–12.73) | 0.001 |
| Decreased | 5 (5.15) | 5 (6.58) | 0 (0) | 0.582 |
| Normal | 92 (94.85) | 71 (93.42) | 21 (100) | |
| MON (G/L) | 0.33 (0.25–0.5) | 0.32 (0.19–0.48) | 0.35 (0.29–0.54) | 0.059 |
| Decreased | 85 (87.63) | 69 (90.79) | 16 (76.19) | 0.126 |
| Normal | 12 (12.37) | 7 (9.21) | 5 (23.81) | |
| HGB (G/L) | 129 (121–140) | 128 (121–140.5) | 132 (118–137) | 0.976 |
| Decreased | 51 (52.58) | 41 (53.95) | 10 (47.62) | 0.630 |
| Normal | 46 (47.42) | 35 (46.05) | 11 (52.38) | |
| PLT (G/L) | 187 (149–233) | 192 (155–231.5) | 163 (131–237) | 0.160 |
| Decreased | 11 (11.34) | 6 (7.89) | 5 (23.81) | 0.091 |
| Normal | 83 (85.57) | 67 (88.16) | 16 (76.19) | |
| Increased | 3 (3.09) | 3 (3.95) | 0 (0) | |
| PT (s) | 13.5 (12.5–15) | 13.15 (12.4–14.55) | 15.6 (13–17.4) | 0.005 |
| Normal | 83 (85.57) | 70 (92.11) | 13 (61.9) | 0.002 |
| Increased | 14 (14.43) | 6 (7.89) | 8 (38.1) | |
| APTT (s) | 34.8 (32.4–40.1) | 34.05 (32.25–38.45) | 41.5 (37.7–43.9) | 0.005 |
| Decreased | 3 (3.09) | 3 (3.95) | 0 (0) | 0.176 |
| Normal | 78 (80.41) | 63 (82.89) | 15 (71.43) | |
| Increased | 16 (16.49) | 10 (13.16) | 6 (28.57) | |
| ALT (U/L) | 25 (15–44) | 24.0 (14–44.5) | 26 (20–39) | 0.534 |
| Decreased | 38 (39.18) | 32 (42.11) | 6 (28.57) | 0.469 |
| Normal | 53 (54.64) | 40 (52.63) | 13 (61.9) | |
| Increased | 6 (6.19) | 4 (5.26) | 2 (9.52) | |
| AST (U/L) | 29 (20–47) | 27 (20–43.5) | 42 (25–66) | 0.048 |
| Decreased | 11 (11.34) | 10 (13.16) | 1 (4.76) | 0.028 |
| Normal | 68 (70.1) | 56 (73.68) | 12 (57.14) | |
| Increased | 18 (18.56) | 10 (13.16) | 8 (38.1) | |
| TBIL (umol/L) | 9.14 (6.76–13.98) | 8.63 (6.67–12.37) | 9.62 (8.06–23.75) | 0.057 |
| Normal | 86 (88.66) | 71 (93.42) | 15 (71.43) | 0.012 |
| Increased | 11 (11.34) | 5 (6.58) | 6 (28.57) | |
| DBIL (umol/L) | 3.04 (1.94–5.00) | 2.69 (1.88–4.13) | 5.16 (3.04–8.15) | 0.002 |
| Normal | 72 (74.23) | 62 (81.58) | 10 (47.62) | 0.004 |
| Increased | 25 (25.77) | 14 (18.42) | 11 (52.38) | |
| ALB (G/L) | 35.1 (32.6–38)/35.24±3.43 | 35.59±3.51 | 33.98±2.94 | 0.056 |
| Decreased | 46 (47.42) | 32 (42.11) | 14 (66.67) | 0.053 |
| Normal | 51 (52.58) | 44 (57.89) | 7 (33.33) | |
| CRE (umol/L) | 66 (56–83) | 65.5 (54.5–75.5) | 83 (64–95) | 0.004 |
| Decreased | 29 (29.9) | 25 (32.89) | 4 (19.05) | 0.004 |
| Normal | 63 (64.95) | 50 (65.79) | 13 (61.90) | |
| Increased | 5 (5.15) | 1 (1.32) | 4 (19.05) | |
| BUN (mmol/L) | 6.08 (4.78–7.72) | 5.88 (4.61–7.45) | 7.37 (6.12–9.69) | 0.005 |
| Decreased | 9 (9.28) | 8 (10.53) | 1 (4.76) | 0.021 |
| Normal | 53 (54.64) | 46 (60.53) | 7 (33.33) | |
| Increased | 35 (36.08) | 22 (28.95) | 13 (61.90) | |
| H-CRP (mg/L) | 45.51 (23.89–89.02) | 35.6 (21.53–82.39) | 88.88 (59.63–99.67) | 0.004 |
| Normal | 7 (7.22) | 6 (7.89) | 1 (4.76) | 0.624 |
| Increased | 90 (92.78) | 70 (92.11) | 20 (95.24) | |
| CK | 67.2 (43.1–139.1) | 64.15 (39.95–100.85) | 93.7 (50.4–185.0) | 0.121 |
| Decreased | 2 (2.06) | 1 (1.32) | 1 (4.76) | 0.279 |
| Normal | 80 (82.48) | 65 (85.53) | 15 (71.43) | |
| Increased | 15 (15.46) | 10 (13.16) | 5 (23.81) | |
| CKMB | 17.2 (14.0–22.0) | 16.5 (13.15–19.80) | 21 (17.2–25.0) | 0.005 |
| Normal | 82 (84.54) | 68 (89.47) | 14 (66.67) | 0.018 |
| Increased | 15 (15.46) | 8 (10.53) | 7 (15.46) | |
| * P values were calculated by the Student’s t-test or Wilcoxon test for continuous variables. The Chi-square test for categorical variables, and the Fisher exact test was used when the data were limited. WBC – white blood cell; LYM – lymphocyte; NEU – neutrophil; MON – monocyte; ALB – albumin; ALP – alkaline phosphatase; HGB – hemoglobin; PLT – platelet; PT – prothrombin; APTT – activated partial thromboplastin time; ALT – alanine aminotransferase; AST – glutamic oxaloacetylase; TBIL – total bilirubin; DBIL – direct bilirubin; ALB – albumin; CRE – creatinine; BUN – urea nitrogen; H-CRP – hypersensitive C-reactive protein; CK – creatine kinase; CKMB – creatine Kinase isomer-MB. | ||||