Urinary Metabonomic Profiling Discriminates Between Children with Autism and Their Healthy Siblings

25 November 2020: Clinical Research

Yujie Liang ^12AE , Zhou Xiao ^1B , Xiaoyin Ke ^1F , Paul Yao ^1E , Yangxia Chen ^1B , Ling Lin ^12F , Jianping Lu ^12AG*

DOI: 10.12659/MSM.926634

Med Sci Monit 2020; 26:e926634

Table 2 Summary of the discriminant metabolites accountable for the separation of metabolic profiles between control vs. ASD groups.

Metabolites	P-value	r	VIP
Butyrate: 1.55(mc), 2.19(m)	3.150×10	−0.580	3.337
Tryptophan: 4.04(s),3.47(m)	4.586×10	0.513	1.708
Citrate: 2.55(d), 2.68(d)	2.066×10	−0.650	4.072
Creatine: 3.04(s), 3.93(s)	5.166×10	0.612	9.475
Lactate: 1.34(d), 4.11(q)	2.066×10	−0.656	1.502
Pantothenate: 0.88(s), 0.93(s), 7.98(s)	2.066×10	−0.569	1.245
Serotonin: 6.87(d), 7.13(d), 7.32(s)	9.015×10	0.553	1.558
Taurine: 3.27(t), 3.44(t)	2.176×10	0.552	5.006
Trigonelline: 4.44(s), 8.01(m), 8.84(t), 9.13(s)	2.589×10	−0.575	1.183
Melatonin: 3.84(s), 1.92(s)	8.418×10	−0.545	2.072