Prognostic Value of Acute-On-Chronic Liver Failure (ACLF) Score in Critically Ill Patients with Cirrhosis and ACLF

26 September 2020: Database Analysis

Xinran Lin ^1ABCDEF* , Xielin Huang ^2ABCDEF* , Li Wang ^1BC , Shuyi Feng ^1B , Xiaofu Chen ^1BC , Weimin Cai ^1B , Zhiming Huang ^1A*

DOI: 10.12659/MSM.926574

Med Sci Monit 2020; 26:e926574

Table 5 Diagnostic accuracy of different scoring systems in predicting 28-day mortality at the optimal cutoff point.

Prognostic models	Cut-off point	Sensitivity	Specificity	Youden index	PLR	NLR	PPV	NPV
AARC ACLF	9.5	0.67	0.72	0.39	2.41	0.46	0.50	0.84
Child-Pugh score	8	0.79	0.51	0.31	1.62	0.40	0.40	0.86
MELD	17	0.72	0.68	0.39	2.22	0.42	0.47	0.86
MELD-Na	19	0.75	0.64	0.39	1.17	0.39	0.46	0.86
SOFA	8	0.76	0.65	0.41	2.18	0.37	0.47	0.87
CLIF-SOFA	9	0.69	0.71	0.40	2.39	0.43	0.49	0.85
CLIF-C ACLFs	56	0.69	0.73	0.42	2.56	0.43	0.51	0.85
NLR – negative likelihood ratio; NPV – negative predictive value; PLR – positive likelihood ratio; PPV – positive predictive value.