Prognostic Value of Acute-On-Chronic Liver Failure (ACLF) Score in Critically Ill Patients with Cirrhosis and ACLF

26 September 2020: Database Analysis

Xinran Lin ^1ABCDEF* , Xielin Huang ^2ABCDEF* , Li Wang ^1BC , Shuyi Feng ^1B , Xiaofu Chen ^1BC , Weimin Cai ^1B , Zhiming Huang ^1A*

DOI: 10.12659/MSM.926574

Med Sci Monit 2020; 26:e926574

Table 3 Univariate and multivariate Cox proportional hazards model of association between clinical parameters and 28-day mortality.

Variables	Univariate analysis			Multivariate analysis
Variables	HR	95% CI	P	HR	95% CI	P
Age (years)	0.995	0.984, 1.005	0.332
Sex	0.981	0.744, 1.294	0.893
Ethnicity
White	Reference	Reference	Reference
Black	0.528	0.279, 1.002	0.051
Other	1.706	1.259, 2.312	0.001
MAP (mmHg)	0.959	0.945, 0.972		0.977	0.958, 0.997	0.025
PaO2/FiO2	0.999	0.998, 1.000	0.005	0.998	0.997, 0.999	0.004
24-h urine output (ml)	0.999	0.999, 1.000
Vasopressin used	2.120	1.629, 2.761		1.582	1.097, 2.281	0.014
Ventilator	1.491	1.135, 1.957	0.004
RRT	1.908	1.317, 2.763	0.001
ALT (IU/l)	1.000	1.000, 1.001	0.009
AST (IU/l)	1.000	1.000, 1.000		1.000	1.000, 1.000	0.006
Albumin (g/dl)	0.823	0.644, 1.050	0.118	0.761	0.595, 0.975	0.031
BUN (mg/dl)	1.009	1.006, 1.013
Glucose (mg/dl)	0.993	0.990, 0.997	0.001
Platelet (10/l)	0.996	0.994, 0.998		0.997	0.995, 1.000	0.037
WBC (10/l)	1.025	1.012, 1.039		1.020	1.003, 1.038	0.019
RDW	1.111	1.062, 1.162
Potassium (mEq/l)	1.034	0.906, 1.180	0.619
Sodium (mEq/l)	0.977	0.959, 0.996	0.016
AARC ACLF	1.434	1.335, 1.539		1.375	1.247, 1.516
Ascites	1.357	1.027, 1.791	0.035
Variceal bleeding	1.138	0.790, 1.640	0.487
SBP	1.894	1.282, 2.799	0.003	1.850	1.129, 3.034	0.015
HRS	1.813	1.347, 2.440
HRs and P values were estimated using Cox proportional hazard model. CI – confidence interval; HR – hazard ratio; MAP – mean arterial pressure; RRT – renal replacement therapy; ALT – alanine aminotransferase; AST – aspartate aminotransferase; BUN – blood urea nitrogen; WBC – white blood cell; RDW – red blood cell volume distribution width; SBP – spontaneous bacterial peritonitis; HRS – hepatorenal syndrome.