07 January 2021: Clinical Research
Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer
Dawei Ning 1BCEF , Kai Cui 2BC , Min Liu 2D , Yang Ou 3BCEF , Zhendan Wang 4B , Benkui Zou 5B , Yangyang Shen 6B , Xinyang Lu 7B , Sheng Li 8AG* , Pang Li 9AB*DOI: 10.12659/MSM.926565
Med Sci Monit 2021; 27:e926565
Table 8 Univariate and multivariate analysis of CellSearch-derived and other factors affecting progression-free survival in patients with gastric cancer.
| Independent factors | Hazard ratio | 95% CI | P | Hazard ratio | 95% CI | P |
|---|---|---|---|---|---|---|
| CTC (CellSearch) (Yes/No) | 2.556 | 1.278–5.109 | 0.512 | 0.157–1.667 | 0.266 | |
| CTC (≤1/>1) | 5.824 | 2.452–13.833 | 5.367 | 0.427–67.416 | 0.193 | |
| CTC (≤2/>2) | 6.292 | 2.566–15.431 | 8.630 | 0.421–177.118 | 0.162 | |
| CTC (≤3/>3) | 5.358 | 2.136–13.443 | 0.023 | 0.001–0.395 | ||
| CTC (≤4/>4) | 4.859 | 1.775–13.300 | 1.618 | 0.293–8.947 | 0.581 | |
| Age (≤60/>60) | 1.527 | 0.790–2.951 | 0.208 | |||
| Sex (Male/Female) | 1.449 | 0.634–3.314 | 0.380 | |||
| KPS (70–80/90–100) | 0.685 | 0.367–1.279 | 0.235 | |||
| Platelet count | 1.001 | 0.997–1.005 | 0.724 | |||
| N/L | 1.116 | 0.905–1.377 | 0.305 | |||
| CEA ( | 1.437 | 0.878–2.352 | 0.149 | |||
| CA199 ( | 1.036 | 0.160–0.818 | 0.886 | |||
| Pathological stage (I–II/III–IV) | 14.377 | 3.424–60.372 | 15.475 | 2.426–98.725 | ||
| Distant metastasis (Yes/No) | 11.478 | 4.451–29.595 | 10.310 | 2.796–38.019 | ||
| Lymph node metastasis (Yes/No) | 5.177 | 1.820–14.727 | 0.603 | 0.152–2.383 | 0.470 | |
| Tumor size ( | 2.580 | 1.637–4.067 | 1.385 | 0.588–3.263 | 0.456 | |
| Vascular invasion(Yes/No) | 1.912 | 1.266–2.889 | 0.917 | 0.420–2.003 | 0.829 |