Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer

Dawei Ning; Kai Cui; Min Liu; Yang Ou; Zhendan Wang; Benkui Zou; Yangyang Shen; Xinyang Lu; Sheng Li; Pang Li

doi:10.12659/MSM.926565

07 January 2021: Clinical Research

Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer

Dawei Ning ^1BCEF , Kai Cui ^2BC , Min Liu ^2D , Yang Ou ^3BCEF , Zhendan Wang ^4B , Benkui Zou ^5B , Yangyang Shen ^6B , Xinyang Lu ^7B , Sheng Li ^8AG* , Pang Li ^9AB*

DOI: 10.12659/MSM.926565

Med Sci Monit 2021; 27:e926565

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Background Material and Methods Results Discussion Conclusions References

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Table 7 Correlation between circulating tumor microemboli detected with the CTC-Biopsy system and clinicopathological factors.

Factors	Positive (n=15)	Negative (n=44)	P	Stage I–II (n=2)	P	Stage III–IV (n=13)	P
Age			0.330^*		1^**		0.427^*
≥60	9	20		1		8
	6	24		1		5
Sex			0.445^*		1^**		0.237^*
Male	11	38		2		9
Female	4	6		0		4
Lymphocyte (×10/L)	1.50±0.52	1.66±0.54	0.307^#	1.89±0.04	0.950^#	1.43±0.54	0.711^#
Neutrophils (×10/L)	3.70±1.12	4.04±1.71	0.476^#	3.65±1.13	0.635^#	3.71±1.17	0.716^#
Platelet (×10/L)	281.87±60.93	254.82±89.42	0.282^#	345.50±95.46	0.109^#	272.08±52.85	0.671^#
N/L	2.88±1.55	2.72±1.57	0.727^#	1.94±0.64	0.654^#	3.03±1.61	0.864^#
D-dimer	0.87±1.15	2.04±4.33	0.306^#	0.55±0.07	0.703^#	0.92±1.23	0.260^#
Serum CEA			0.903^*		^**		0.324^*
	8	26		0		8
≥3.4	6	16		1		5
Other	1	2		1		0
Serum CA199			0.820^*		0.154^**		0.287^*
	11	34		1		10
≥39	3	6		0		3
Other	1	4		1		0
Lymph node metastasis			0.094^*		1^**		1^**
No	2	17		2		0
Yes	13	27		0		13
Tumor location			0.625^*		0.638^**		0.907^*
Upper third	7	16		1		6
Middle third	3	7		0		3
Lower third	5	21		1		4
Tumor size, cm			0.211^*		0.605^**		0.339^*
	24	5		2		3
≥5	15	9		0		9
Other	5	1		0		1
Vascular invasion			0.501^*		0.501^**		0.685^*
No	9	32		2		7
Yes	4	6		0		4
Other	2	6		0		2
Differentiation level			0.277^*		0.346^**		^**
Low	11	21		0		11
Low medium	3	7		1		2
Medium	1	9		1		0
High	0	2		0		0
Other	0	5		0		0
^* χ test; ^** Fisher accurate inspection; ^# Student’s t-test.

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Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer

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