07 January 2021>: Clinical Research
Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer
Dawei Ning 1BCEF , Kai Cui 2BC , Min Liu 2D , Yang Ou 3BCEF , Zhendan Wang 4B , Benkui Zou 5B , Yangyang Shen 6B , Xinyang Lu 7B , Sheng Li 8AG* , Pang Li 9AB*DOI: 10.12659/MSM.926565
Med Sci Monit 2021; 27:e926565
Table 6 Correlation between circulating tumor cells detected with the CTC-Biopsy system and clinicopathological factors.
Factors | Positive (n=35) | Negative (n=24) | P | Stage I–II (n=8) | P | Stage III–IV (n=27) | P |
---|---|---|---|---|---|---|---|
Age | 0.914* | 0.552* | 0.427* | ||||
≥60 | 17 | 12 | 4 | 13 | |||
18 | 12 | 4 | 14 | ||||
Sex | 0.451* | 0.202* | 0.177* | ||||
Male | 28 | 21 | 8 | 20 | |||
Female | 7 | 3 | 0 | 7 | |||
Lymphocyte (×10/L) | 1.58±0.50 | 1.67±0.58 | 0.51# | 1.75±0.36 | 0.192# | 1.53±0.53 | 0.411# |
Neutrophils (×10/L) | 3.97±1.66 | 3.94±1.49 | 0.94# | 4.96±1.97 | 0.084# | 3.67±1.47 | 0.327# |
Platelet (×10/L) | 266.00±70.65 | 128.63±26.17 | 0.64# | 273.38±84.76 | 0.487# | 263.81±67.61 | 0.988# |
N/L | 2.82±1.53 | 2.82±1.53 | 0.72# | 3.01±1.67 | # | 2.77±1.51 | 0.278# |
D-dimer | 2.01±4.58 | 1.32±2.15 | 0.451# | 0.74±0.49 | 0.459# | 2.40±5.19 | 0.297# |
Serum CEA | 0.964* | 0.355* | 0.569* | ||||
20 | 14 | 5 | 15 | ||||
≥3.4 | 13 | 9 | 2 | 11 | |||
Other | 2 | 1 | 1 | 1 | |||
Serum CA199 | 0.882* | ** | 0.367* | ||||
26 | 19 | 5 | 21 | ||||
≥39 | 6 | 3 | 1 | 5 | |||
Other | 3 | 2 | 2 | 1 | |||
Lymph node metastasis | 0.498* | 0.737* | 1** | ||||
No | 9 | 9 | 7 | 2 | |||
Yes | 26 | 15 | 1 | 25 | |||
Tumor location | 0.319* | 0.581* | 0.093* | ||||
Upper third | 22 | 11 | 3 | 9 | |||
Middle third | 8 | 2 | 1 | 7 | |||
Lower third | 15 | 11 | 4 | 11 | |||
Tumor size, cm | 0.301* | 0.396* | 0.807* | ||||
15 | 14 | 6 | 9 | ||||
≥5 | 15 | 9 | 1 | 14 | |||
Other | 5 | 1 | 1 | 4 | |||
Vascular invasion | 0.388* | 0.243* | 0.685* | ||||
No | 22 | 19 | 7 | 15 | |||
Yes | 7 | 3 | 0 | 7 | |||
Other | 6 | 2 | 1 | 5 | |||
Differentiation level | 0.196* | 0.753* | * | ||||
Low | 22 | 10 | 2 | 20 | |||
Low medium | 7 | 3 | 2 | 5 | |||
Medium | 3 | 7 | 2 | 1 | |||
High | 1 | 1 | 1 | 1 | |||
Other | 2 | 3 | 1 | 0 | |||
* χ test; ** Fisher accurate inspection; # Student’s t-test. |