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07 January 2021: Clinical Research

Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer

Dawei Ning 1BCEF , Kai Cui 2BC , Min Liu 2D , Yang Ou 3BCEF , Zhendan Wang 4B , Benkui Zou 5B , Yangyang Shen 6B , Xinyang Lu 7B , Sheng Li 8AG* , Pang Li 9AB*

DOI: 10.12659/MSM.926565

Med Sci Monit 2021; 27:e926565

Table 5 Correlation between circulating tumor cells detected with the CellSearch system and clinicopathological factors.

FactorsPositive (n=16)Negative (n=43)PStage I–II (n=1)PStage III–IV (n=15)P
Age0.937* 1** 0.935*
 ≥6082118
82207
Sex0.378* 1** 0.414*
 Male1237111
 Female4604
Lymphocyte (×10/L)1.30±0.381.74±0.56# 1.290.148# 1.29±0.390.085#
Neutrophils (×10/L)4.62±1.853.71±1.41# 5.820.327# 4.54±1.88#
Platelet (×10/L)269.00±83.03258.98±84.430.685# 181.000.351# 274.87±82.440.527#
N/L3.86±1.752.35±1.26# 4.510.0803.82±1.81#
D-dimer3.54±6.331.03±1.780.138# 0.900.918# 3.71±6.510.0549#
Serum CEA0.770* 0.730** 0.904*
82617
 ≥3.471507
 Other1201
Serum CA199* 0.838* *
93618
 ≥396306
 Other1401
Lymph node metastasis* 1** 0.519*
 No11710
 Yes1526015
Tumor location0.026* 0.080* 0.254*
 Upper third61706
 Middle third6415
 Lower third42204
Tumor size, cm* 0.784* *
32612
 ≥591509
 Other4204
Vascular invasion* 0.892* *
 No63515
 Yes4604
 Other6206
Differentiation level0.650** 0.404** 0.404**
 Low1022010
 Low medium2811
 Medium2802
 High2200
 Other0302
* χ test;
** Fisher accurate inspection;
# Student’s t-test.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750