07 January 2021>: Clinical Research
Comparison of CellSearch and Circulating Tumor Cells (CTC)-Biopsy Systems in Detecting Peripheral Blood Circulating Tumor Cells in Patients with Gastric Cancer
Dawei Ning 1BCEF , Kai Cui 2BC , Min Liu 2D , Yang Ou 3BCEF , Zhendan Wang 4B , Benkui Zou 5B , Yangyang Shen 6B , Xinyang Lu 7B , Sheng Li 8AG* , Pang Li 9AB*DOI: 10.12659/MSM.926565
Med Sci Monit 2021; 27:e926565
Table 5 Correlation between circulating tumor cells detected with the CellSearch system and clinicopathological factors.
Factors | Positive (n=16) | Negative (n=43) | P | Stage I–II (n=1) | P | Stage III–IV (n=15) | P |
---|---|---|---|---|---|---|---|
Age | 0.937* | 1** | 0.935* | ||||
≥60 | 8 | 21 | 1 | 8 | |||
8 | 22 | 0 | 7 | ||||
Sex | 0.378* | 1** | 0.414* | ||||
Male | 12 | 37 | 1 | 11 | |||
Female | 4 | 6 | 0 | 4 | |||
Lymphocyte (×10/L) | 1.30±0.38 | 1.74±0.56 | # | 1.29 | 0.148# | 1.29±0.39 | 0.085# |
Neutrophils (×10/L) | 4.62±1.85 | 3.71±1.41 | # | 5.82 | 0.327# | 4.54±1.88 | # |
Platelet (×10/L) | 269.00±83.03 | 258.98±84.43 | 0.685# | 181.00 | 0.351# | 274.87±82.44 | 0.527# |
N/L | 3.86±1.75 | 2.35±1.26 | # | 4.51 | 0.080 | 3.82±1.81 | # |
D-dimer | 3.54±6.33 | 1.03±1.78 | 0.138# | 0.90 | 0.918# | 3.71±6.51 | 0.0549# |
Serum CEA | 0.770* | 0.730** | 0.904* | ||||
8 | 26 | 1 | 7 | ||||
≥3.4 | 7 | 15 | 0 | 7 | |||
Other | 1 | 2 | 0 | 1 | |||
Serum CA199 | * | 0.838* | * | ||||
9 | 36 | 1 | 8 | ||||
≥39 | 6 | 3 | 0 | 6 | |||
Other | 1 | 4 | 0 | 1 | |||
Lymph node metastasis | * | 1** | 0.519* | ||||
No | 1 | 17 | 1 | 0 | |||
Yes | 15 | 26 | 0 | 15 | |||
Tumor location | 0.026* | 0.080* | 0.254* | ||||
Upper third | 6 | 17 | 0 | 6 | |||
Middle third | 6 | 4 | 1 | 5 | |||
Lower third | 4 | 22 | 0 | 4 | |||
Tumor size, cm | * | 0.784* | * | ||||
3 | 26 | 1 | 2 | ||||
≥5 | 9 | 15 | 0 | 9 | |||
Other | 4 | 2 | 0 | 4 | |||
Vascular invasion | * | 0.892* | * | ||||
No | 6 | 35 | 1 | 5 | |||
Yes | 4 | 6 | 0 | 4 | |||
Other | 6 | 2 | 0 | 6 | |||
Differentiation level | 0.650** | 0.404** | 0.404** | ||||
Low | 10 | 22 | 0 | 10 | |||
Low medium | 2 | 8 | 1 | 1 | |||
Medium | 2 | 8 | 0 | 2 | |||
High | 2 | 2 | 0 | 0 | |||
Other | 0 | 3 | 0 | 2 | |||
* χ test; ** Fisher accurate inspection; # Student’s t-test. |