10 October 2020>: Clinical Research
A Nomogram for Prediction of Survival in Patients After Gastrectomy Within Enhanced Recovery After Surgery (ERAS): A Single-Center Retrospective Study
Yuqi Sun 1DE , Zequn Li 1A , Xiaodong Liu 1AF , Shougen Cao 1CD , Xuechao Liu 1C , Chuan Hu 2F , Yulong Tian 1AD , Jianfei Xu 1E , Daosheng Wang 1G , Xin Zhou 1F , Yanbing Zhou 1AG*DOI: 10.12659/MSM.926347
Med Sci Monit 2020; 26:e926347
Table 3 Univariate and multivariate Cox proportional hazard analyses of OS with GC patients.
Variable | Univariate analysis | Multivariate analysis | ||
---|---|---|---|---|
HR (95%CI) | P-value | HR (95%CI) | P-value | |
Sex (Male vs. Female) | 0.822 (0.554–1.221) | 0.333 | ||
Age | 2.044 (1.411–2.961) | 1.802 (1.199–2.710) | 0.005 | |
BMI | 0.681 (0.456–1.016) | 0.060 | ||
ASA classification | 0.562 | |||
I | Reference | |||
II | 1.149 (0.466–2.831) | 0.763 | ||
III | 1.389 (0.547–3.527) | 0.489 | ||
Comorbidity | 1.100 (0.773–1.566) | 0.597 | ||
Tumor size | 0.958 | |||
≤3 | Reference | Reference | ||
3–5 | 2.462 (1.494–4.055) | 0.956 (0.557–1.642) | 0.871 | |
>5 | 4.233 (2.684–6.675) | 0.924 (0.539–1.582) | 0.772 | |
Tumor location | 0.130 | |||
Cardia/fundus | Reference | Reference | ||
Body | 0.499 (0.283–0.878) | 0.016 | 0.552 (0.301–1.011) | 0.054 |
Antrum/pylorus | 0.376 (0.238–0.594) | 0.652 (0.396–1.075) | 0.094 | |
Tumor differentiation | 0.033 | 0.981 | ||
Well | Reference | |||
Moderate | 5.205 (0.684–39.585) | 0.111 | 1.148 (0.135–9.773) | 0.900 |
Poor | 8.237 (1.150–58.988) | 0.036 | 1.091 (0.133–8.961) | 0.936 |
Borrmann type | 0.150 | |||
I | Reference | Reference | ||
II | 1.209 (0.483–3.030) | 0.685 | 0.464 (0.174–1.233) | 0.124 |
III | 3.030 (1.335–6.968) | 0.008 | 0.780 (0.319–1.905) | 0.585 |
IV | 7.509 (2.814–20.036) | 0.985 (0.326–2.981) | 0.979 | |
Intraoperative blood transfusion | 1.840 (1.056–3.205) | 0.031 | 1.598 (0.882–2.895) | 0.122 |
Surgical approach (laparoscopic open) | 1.633 (0.826–3.229) | 0.159 | ||
Gastrectomy type (subtotal total gastrectomy) | 2.291 (1.447–3.626) | 1.000 (0.600–1.664) | 0.999 | |
Extent of LN dissection (D2 D2+) | 0.963 (0.660–1.404) | 0.844 | ||
Depth of invasion | 0.001 | |||
T1 | Reference | Reference | ||
T2 | 2.747 (0.804–9.386) | 0.107 | 3.150 (0.791–12.543) | 0.104 |
T3 | 8.373 (3.001–23.364) | 10.323 (1.624–65.630) | 0.013 | |
T4a | 19.150 (6.981–52.535) | 20.236 (2.909–140.750) | 0.002 | |
T4b | 39.875 (12.264–129.649) | 35.632 (4.744–267.653) | 0.001 | |
Depth of invasion | ||||
N0 | Reference | Reference | ||
N1 | 2.634 (1.382–5.020) | 0.003 | 2.305 (1.117–4.758) | 0.024 |
N2 | 6.274 (3.622–10.866) | 4.359 (2.057–9.235) | ||
N3a | 9.898 (5.726–17.110) | 5.330 (2.497–11.378) | ||
N3b | 13.232 (6.375–27.268) | 7.314 (2.822–18.957) | ||
Total LN (continuous) | 1.014 (0.999–1.029) | 0.066 | ||
AJCC pTNM stage | 0.236 | |||
I | Reference | Reference | ||
II | 2.271 (0.952–5.413) | 0.064 | 0.269 (0.057–1.275) | 0.098 |
III | 12.036 (5.864–24.707) | 0.296 (0.046–1.902) | 0.200 | |
Perioperative malnutrition | 1.503 (1.015–2.226) | 0.042 | 1.001 (0.638–1.571) | 0.996 |
Complications | 1.922 (1.288–2.868) | 0.001 | 1.648 (1.072–2.532) | 0.023 |
Postoperative chemotherapy | 2.197 (1.537–3.141) | 1.037 (0.691–1.556) | 0.859 | |
HR – hazard ratio; CI – confidence interval. |