27 September 2020: Database Analysis
A Network Pharmacological Approach to Investigate the Mechanism of Action of Active Ingredients of and Their Potential Targets in Treatment of Alzheimer’s Disease
Yajuan Li ABCDEF , Qin Yang BF , Yang Yu AG*DOI: 10.12659/MSM.926295
Med Sci Monit 2020; 26:e926295
Table 1 Potential active components of Epimedii Herba.
| Molecule Name | OB (%) | DL | |
|---|---|---|---|
| MOL000622 | Magnograndiolide | 63.71 | 0.19 |
| MOL004367 | olivil | 62.23 | 0.41 |
| MOL004388 | 6-hydroxy-11,12-dimethoxy-2,2-dimethyl-1,8-dioxo-2,3,4,8-tetrahydro-1H-isochromeno[3,4-h]isoquinolin-2-ium | 60.64 | 0.66 |
| MOL004382 | Yinyanghuo A | 56.96 | 0.77 |
| MOL004396 | 1,2-bis(4-hydroxy-3-methoxyphenyl)propan-1,3-diol | 52.31 | 0.22 |
| MOL004386 | Yinyanghuo E | 51.63 | 0.55 |
| MOL004391 | 8-(3-methylbut-2-enyl)-2-phenyl-chromone | 48.54 | 0.25 |
| MOL000098 | quercetin | 46.43 | 0.28 |
| MOL004384 | Yinyanghuo C | 45.67 | 0.5 |
| MOL004373 | Anhydroicaritin | 45.41 | 0.44 |
| MOL001645 | Linoleyl acetate | 42.1 | 0.2 |
| MOL000422 | kaempferol | 41.88 | 0.24 |
| MOL004394 | Anhydroicaritin-3-O-alpha-L-rhamnoside | 41.58 | 0.61 |
| MOL004425 | Icariin | 41.58 | 0.61 |
| MOL004380 | C-Homoerythrinan, 1,6-didehydro-3,15,16-trimethoxy-, (3.beta) | 39.14 | 0.49 |
| MOL003542 | 8-Isopentenyl-kaempferol | 38.04 | 0.39 |
| MOL001510 | 24-epicampesterol | 37.58 | 0.71 |
| MOL000359 | sitosterol | 36.91 | 0.75 |
| MOL001771 | poriferast-5-en-3beta-ol | 36.91 | 0.75 |
| MOL000006 | luteolin | 36.16 | 0.25 |
| MOL003044 | Chryseriol | 35.85 | 0.27 |
| MOL001792 | DFV | 32.76 | 0.18 |
| MOL004427 | Icariside A7 | 31.91 | 0.86 |