02 October 2020: Clinical Research
Sodium-Glucose Cotransporter-2 Inhibitor Immediately Decreases Serum Uric Acid Levels in Type 2 Diabetic Patients
Naro Ohashi 1ABCDEF* , Taro Aoki 1BCE , Takashi Matsuyama 1BCE , Sayaka Ishigaki 2BCE , Shinsuke Isobe 1BCE , Tomoyuki Fujikura 1A , Takuya Hashimoto 3ABDE , Daisuke Tsuriya 3ABDE , Hiroshi Morita 3ABDE , Akihiko Kato 2AD , Hideo Yasuda 1ACDEDOI: 10.12659/MSM.926086
Med Sci Monit 2020; 26:e926086
Table 5 Multiple linear regression analyses of the percentage changes in serum uric acid levels from baseline to 6 months after sodium-glucose cotransporter-2 inhibitor administration.
| Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|
| R=0.39 | p=0.48 | R=0.40 | p=0.66 | R=0.63 | p=0.015 | R=0.65 | p=0.035 | |
| β | p | β | p | β | p | β | p | |
| Age (year) | −0.37 | 0.15 | −0.36 | 0.19 | −0.43 | 0.023 | −0.43 | 0.030 |
| Sex | −0.082 | 0.75 | −0.067 | 0.82 | −0.030 | 0.87 | −0.031 | 0.88 |
| Change of BMI (%) | 0.079 | 0.78 | 0.069 | 0.73 | ||||
| Change of FE (%) | 0.066 | 0.80 | 0.065 | 0.81 | ||||
| Change of sCr (%) | 0.41 | 0.038 | 0.42 | 0.041 | ||||
| BMI – body mass index, FE – fractional excretion of uric acid, sCr – serum creatinine. | ||||||||