03 October 2020>: Clinical Research
Effects and Mechanisms of Dapagliflozin Treatment on Ambulatory Blood Pressure in Diabetic Patients with Hypertension
Zirui Hao 1BCDE , Yue Sun 1BF , Yingzhen Wen 1BF , Lijuan Cui 1BF , Guiping Li 1DF , Yan Liu 2AG*DOI: 10.12659/MSM.925987
Med Sci Monit 2020; 26:e925987
Table 4 Relationship between 24-h ABP and dapagliflozin treatment.
β | R2 | P | |
---|---|---|---|
24-h SBP | |||
Unadjusted | −0.58 | 0.37 | |
Adjusted model 1 | −0.29 | 0.25 | 0.02 |
Adjusted model 2 | −0.12 | 0.14 | 0.10 |
24-h DBP | |||
Unadjusted | −0.14 | 0.10 | 0.18 |
Adjusted model 1 | −0.06 | 0.05 | 0.34 |
Adjusted model 2 | −0.02 | 0.02 | 0.63 |
Daytime SBP | |||
Unadjusted | −0.62 | 0.41 | |
Adjusted model 1 | −0.33 | 0.32 | 0.009 |
Adjusted model 2 | −0.20 | 0.19 | 0.06 |
Daytime DBP | |||
Unadjusted | −0.16 | 0.11 | 0.12 |
Adjusted model 1 | −0.09 | 0.05 | 0.23 |
Adjusted model 2 | −0.03 | 0.02 | 0.40 |
Nighttime SBP | |||
Unadjusted | −0.30 | 0.26 | 0.04 |
Adjusted model 1 | −0.11 | 0.12 | 0.09 |
Adjusted model 2 | −0.07 | 0.08 | 0.21 |
Nighttime DBP | |||
Unadjusted | −0.10 | 0.14 | 0.32 |
Adjusted model 1 | −0.07 | 0.06 | 0.48 |
Adjusted model 2 | −0.03 | 0.02 | 0.63 |
SBP – systolic blood pressure; DBP – diastolic blood pressure. Model 1: adjusted for age, female sex, body mass index, estimated glomerular filtration rate, medication use at follow-up (aspirin, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, calcium channel blocker, beta-blocker, and metformin); and glycated hemoglobin A1c, urine albumin-creatinine ratio and 24-h urine volume at follow-up. Model 2: was additionally adjusted for serum uric acid and 24-h urinary uric acid excretion at follow-up. |