06 October 2020: Database Analysis
Creation of a Prognostic Risk Prediction Model for Lung Adenocarcinoma Based on Gene Expression, Methylation, and Clinical Characteristics
Honggang Ke 1CD* , Yunyu Wu 2DEF* , Runjie Wang 3CDF , Xiaohong Wu 4AB*DOI: 10.12659/MSM.925833
Med Sci Monit 2020; 26:e925833
Table 4 Functional enrichment analysis results for 265 candidate genes.
| Category | Term | Count | P value | Genes |
|---|---|---|---|---|
| Biologic process | GO: 0032409 ~ regulation of transporter activity | 6 | 0.0002 | PLCG2, NDFIP1, PKD2, FKBP1B, NKX2-5, SYNGR3 |
| GO: 0009611 ~ response to wounding | 21 | 0.0005 | PPARA, A2M, ACHE, BMP2, UCN, FOXA2, EFEMP2, ATRN, CHST2, HOXB13, SERPING1, CD40, TNFRSF1B, THBD, PLSCR4, CTGF, PLA2G7, LTA4H, CFD, PLAU, ACVR1 | |
| GO: 0050777 ~ negative regulation of immune response | 5 | 0.0007 | A2M, IL27RA, NDFIP1, CTLA4, SERPING1 | |
| GO: 0048585 ~ negative regulation of response to stimulus | 8 | 0.0013 | PPARA, A2M, TNFRSF1B, IL27RA, NDFIP1, CTLA4, SERPING1, NT5E | |
| GO: 0015718 ~ monocarboxylic acid transport | 6 | 0.0013 | SLC16A3, SLC25A20, PPARA, SLC16A1, PLA2G1B, SLCO2A1 | |
| GO: 0055082 ~ cellular chemical homeostasis | 16 | 0.0016 | FXYD1, TRPM8, IL6ST, NDFIP1, TP53, FZD2, FKBP1B, CKB, GCKR, PLCG2, CLDN1, PKD2, RGN, SV2A, KCNH2, KCNQ1 | |
| GO: 0050878 ~ regulation of body fluid levels | 9 | 0.0023 | SCT, UCN, THBD, PLSCR4, FOXA2, EFEMP2, SERPING1, CD40, PLAU | |
| GO: 0006869 ~ lipid transport | 9 | 0.0028 | SLC25A20, PPARA, OSBPL3, SORL1, LIPG, PLA2G1B, VPS4B, VLDLR, SLCO2A1 | |
| GO: 0031348 ~ negative regulation of defense response | 5 | 0.0028 | A2M, TNFRSF1B, NDFIP1, SERPING1, NT5E | |
| GO: 0050801 ~ ion homeostasis | 16 | 0.0033 | FXYD1, TRPM8, IL6ST, NDFIP1, TP53, FZD2, CPS1, FKBP1B, CKB, PLCG2, CLDN1, PKD2, RGN, SV2A, KCNH2, KCNQ1 | |
| GO: 0035295 ~ tube development | 11 | 0.0036 | BMP2, FOXA2, CTGF, CRISPLD2, TGFBR1, HOXB13, PCSK5, NKX2-5, HECA, MYCN, ACVR1 | |
| GO: 0006873 ~ cellular ion homeostasis | 15 | 0.0037 | FXYD1, TRPM8, IL6ST, NDFIP1, TP53, FZD2, FKBP1B, CKB, PLCG2, CLDN1, PKD2, RGN, SV2A, KCNH2, KCNQ1 | |
| GO: 0010876 ~ lipid localization | 9 | 0.0045 | SLC25A20, PPARA, OSBPL3, SORL1, LIPG, PLA2G1B, VPS4B, VLDLR, SLCO2A1 | |
| GO: 0019725 ~ cellular homeostasis | 17 | 0.0046 | FXYD1, TRPM8, PDIA2, IL6ST, NDFIP1, TP53, FZD2, FKBP1B, CKB, GCKR, PLCG2, CLDN1, PKD2, RGN, SV2A, KCNH2, KCNQ1 | |
| GO: 0048878 ~ chemical homeostasis | 18 | 0.0049 | FXYD1, TRPM8, IL6ST, NDFIP1, TP53, FZD2, CPS1, FKBP1B, CKB, GCKR, PLCG2, LIPG, CLDN1, PKD2, RGN, SV2A, KCNH2, | |
| KEGG pathway | hsa00562: Inositol phosphate metabolism | 5 | 0.0017 | ISYNA1, PLCG2, SYNJ2, ITPKB, INPP5A |
| hsa04610: Complement and coagulation cascades | 5 | 0.0037 | A2M, THBD, SERPING1, CFD, PLAU | |
| hsa04070: Phosphatidylinositol signaling system | 5 | 0.0046 | PLCG2, SYNJ2, ITPKB, CALML5, INPP5A | |
| hsa00532: Chondroitin sulfate biosynthesis | 3 | 0.0060 | B3GAT1, XYLT1, CHSY1 | |
| hsa05217: Basal cell carcinoma | 4 | 0.0393 | BMP2, TP53, WNT11, FZD2 | |
| hsa00534: Heparan sulfate biosynthesis | 3 | 0.0081 | B3GAT1, XYLT1, HS3ST1 | |
| hsa00590: Arachidonic acid metabolism | 4 | 0.0082 | AKR1C3, CYP2C18, PLA2G1B, LTA4H | |
| hsa04514: Cell adhesion molecules (CAMs) | 6 | 0.0093 | NRCAM, CDH15, CLDN1, CTLA4, CD40, SDC2 | |
| hsa00340: Histidine metabolism | 3 | 0.0098 | HDC, LCMT2, MAOB | |
| KEGG – Kyoto Encyclopedia of Genes and Genomes. | ||||