24 July 2020: Database Analysis
Systematic Analysis of Alternative Splicing Landscape in Pancreatic Adenocarcinoma Reveals Regulatory Network Associated with Tumorigenesis and Immune Response
Jiahua Lu 1234BCE , Shenyu Wei 5BCD , Jianying Lou 6BF , Shengyong Yin 1234DF , Lin Zhou 1234CD , Wu Zhang 78AEG* , Shusen Zheng 1234AEG*DOI: 10.12659/MSM.925733
Med Sci Monit 2020; 26:e925733
Supplementary Table 1 Multivariate Cox regression analysis for alternative splicing (AS) events in each predictive model.
| Type | AS event | Coef | HR | 95% lower | 95% Up | P-value |
|---|---|---|---|---|---|---|
| AA | MRPL4|47484|AA | −8.02 | 3.30E-04 | 2.68E-08 | 4.04 | 0.095098 |
| ITGB1BP1|52617|AA | −1.51 | 0.22 | 0.04 | 1.21 | 0.081335 | |
| CYB561A3|16164|AA | −2.16 | 0.12 | 0.03 | 0.49 | 0.003402 | |
| SWI5|87732|AA | 2.51 | 12.27 | 0.69 | 216.66 | 0.087002 | |
| CELF1|15763|AA | −2.94 | 0.05 | 3.59E-03 | 0.78 | 0.032441 | |
| EML3|16362|AA | −9.34 | 8.82E-05 | 4.39E-09 | 1.77 | 0.064770 | |
| PLCG1|59390|AA | −6.08 | 2.29E-03 | 5.51E-05 | 0.09 | 0.001375 | |
| C19orf33|49601|AA | −8.14 | 2.91E-04 | 4.23E-07 | 0.20 | 0.014598 | |
| SRSF7|53281|AA | 5.00 | 149.15 | 1.82 | 1.22E+04 | 0.026008 | |
| IGSF8|8426|AA | 12.85 | 3.83E+05 | 91.05 | 1.61E+09 | 0.002530 | |
| SLC15A4|93374|AA | −1.59 | 0.20 | 0.03 | 1.51 | 0.119692 | |
| AD | CDK11A|218|AD | −3.19 | 0.04 | 2.25E-03 | 0.75 | 0.031458 |
| SUPT4H1|42666|AD | −14.97 | 3.16E-07 | 4.77E-11 | 2.09E-03 | 0.000853 | |
| NFATC4|26993|AD | −4.08 | 0.02 | 9.09E-04 | 0.31 | 0.006114 | |
| CLASRP|50392|AD | −2.22 | 0.11 | 9.80E-03 | 1.21 | 0.070738 | |
| RAB15|27923|AD | −1.26 | 0.28 | 0.08 | 1.06 | 0.061960 | |
| PTHLH|20910|AD | 1.95 | 7.01 | 1.79 | 27.35 | 0.005089 | |
| NDUFAF2|72172|AD | −6.18 | 2.08E-03 | 2.30E-05 | 0.19 | 0.007177 | |
| CCDC58|66432|AD | −13.82 | 9.95E-07 | 5.96E-10 | 1.66E-03 | 0.000262 | |
| AP | S100A13|7733|AP | −5.05 | 6.40E-03 | 1.66E-04 | 0.25 | 0.006691 |
| UBA1|88907|AP | 4.78 | 118.67 | 1.01 | 1.39E+04 | 0.049376 | |
| COPS7A|19933|AP | 2.10 | 8.16 | 1.16 | 57.64 | 0.035306 | |
| UBE2L6|15862|AP | 13.94 | 1.13E+06 | 1.59 | 8.09E+11 | 0.042642 | |
| SH3KBP1|88641|AP | −1.36 | 0.26 | 0.06 | 1.20 | 0.083722 | |
| SLC7A8|26712|AP | 2.17 | 8.73 | 1.37 | 55.77 | 0.022006 | |
| EIF5A|38908|AP | 3.60 | 36.48 | 0.94 | 1414.49 | 0.053957 | |
| AT | VRK3|51144|AT | 2.09 | 8.10 | 0.51 | 128.40 | 0.137897 |
| RHOF|24898|AT | 5.72 | 305.26 | 3.21 | 2.90E+04 | 0.013794 | |
| CDCA3|19984|AT | −4.26 | 0.01 | 4.28E-04 | 0.47 | 0.016996 | |
| DOCK10|57781|AT | −8.96 | 1.28E-04 | 6.29E-07 | 0.03 | 0.000949 | |
| ZNF506|48683|AT | −3.63 | 0.03 | 1.49E-03 | 0.47 | 0.013505 | |
| ES | CTNND1|15980|ES | −1.16 | 0.31 | 0.09 | 1.11 | 0.072179 |
| CTNND1|15958|ES | −2.19 | 0.11 | 0.02 | 0.71 | 0.020238 | |
| CTAGE5|27377|ES | −5.08 | 6.20E-03 | 2.13E-04 | 0.18 | 0.003117 | |
| UAP1|8750|ES | 6.59 | 725.58 | 10.87 | 4.84E+04 | 0.002116 | |
| NCAPH|54528|ES | −11.51 | 1.00E-05 | 2.19E-08 | 4.58E-03 | 0.000230 | |
| GSE1|37883|ES | −1.46 | 0.23 | 0.06 | 0.86 | 0.028096 | |
| CASP8|56821|ES | −6.82 | 1.09E-03 | 1.10E-05 | 0.11 | 0.003605 | |
| ME | RAD51|30020|ME | −3.24 | 0.04 | 4.58E-04 | 3.33 | 0.152682 |
| RBM39|59248|ME | −3.12 | 0.04 | 0.01 | 0.25 | 0.000410 | |
| ICA1|97384|ME | −5.22 | 5.40E-03 | 1.80E-04 | 0.16 | 0.002600 | |
| TCF7L2|151705|ME | −4.03 | 0.02 | 1.31E-04 | 2.43 | 0.108170 | |
| AMT|64866|ME | 7.26 | 1428.93 | 1.19 | 1.71E+06 | 0.044545 | |
| CERS5|21668|ME | 2.08 | 8.01 | 1.23 | 52.28 | 0.029715 | |
| DNM2|47588|ME | 4.75 | 115.11 | 4.19 | 3162.60 | 0.004994 | |
| RI | SPAG7|38626|RI | −12.53 | 3.63E-06 | 4.86E-11 | 0.27 | 0.028648 |
| CYB561A3|16163|RI | −4.65 | 9.58E-03 | 7.33E-05 | 1.25 | 0.061473 | |
| TMEM9|9354|RI | −1.32 | 0.27 | 0.08 | 0.92 | 0.036773 | |
| HTATIP2|14711|RI | −1.93 | 0.14 | 0.02 | 0.84 | 0.031768 | |
| KRT15|40913|RI | −1.52 | 0.22 | 0.05 | 0.90 | 0.035230 | |
| ALL | S100A13|7733|AP | −4.68 | 9.29E-03 | 2.66E-04 | 0.32 | 0.009853 |
| SH3KBP1|88643|AP | 1.05 | 2.87 | 0.91 | 9.07 | 0.073418 | |
| CDCA3|19984|AT | −2.95 | 0.05 | 1.82E-03 | 1.52 | 0.086090 | |
| COPS7A|19933|AP | 2.42 | 11.20 | 1.61 | 77.90 | 0.014633 | |
| UBE2L6|15862|AP | 15.43 | 5.01E+06 | 2.16 | 1.16E+13 | 0.039109 | |
| SON|60435|AT | −6.49 | 1.52E-03 | 5.80E-06 | 0.40 | 0.022398 | |
| AA – alternate acceptor site; AD – alternate donor site; AP – alternate promoter; AT – alternate terminator; ES – exon skipping; HR – hazard ratio; ME – mutually exclusive exons; RI – retained intron. | ||||||