24 October 2020: Clinical Research
Retrospective Comparison of the Safety and Effectiveness of Dexmedetomidine Versus Standard of Care Before and During Cesarean Delivery in a Maternity Unit in Zhengzhou, China
Wei Zhao 1ABF , Ling Ma 1ABDF , Jingjing Wang 1EFG* , Xiaoyan Shi 2ABCFDOI: 10.12659/MSM.925709
Med Sci Monit 2020; 26:e925709
Table 1 Demographic and clinical characteristics and educational status of pregnant women at the time of admission and neonatal parameters.
| Treatment cohorts | ||||||
|---|---|---|---|---|---|---|
| DX: Dexmedetomidine before and during delivery + normal saline after delivery | SC: Normal saline + dexmedetomidine before and during delivery | CN: Normal saline before, during, and after delivery | ||||
| No. women included | 392 | 115 | 109 | 168 | ||
| Characteristic | P value | |||||
| Age (years) | Minimum | 20 | 20 | 21 | 21 | 0.053 |
| Maximum | 41 | 39 | 41 | 39 | ||
| Mean±SD | 30.36±5.48 | 30.42±5.45 | 29.47±6.41 | 31.08±4.55 | ||
| Gestational age (weeks) | Minimum | 30 | 32 | 30 | 31 | 0.077 |
| Maximum | 42 | 40 | 39 | 42 | ||
| Mean±SD | 35.15±2.46 | 35.89±2.11 | 35.38±3.15 | 34.96±4.15 | ||
| Ethnicity | Han Chinese | 358 (91) | 103 (90) | 100 (92) | 155 (92) | 0.914 |
| Mongolian | 30 (8) | 11 (9) | 8 (7) | 11 (7) | ||
| Tibetan | 4 (1) | 1 (1) | 1 (1) | 2 (1) | ||
| Maternal height (cm) | Minimum | 158 | 160 | 159 | 158 | 0.072 |
| Maximum | 166 | 165 | 166 | 164 | ||
| Mean±SD | 161.53±5.14 | 161.15±5.41 | 162.37±4.49 | 160.95±5.48 | ||
| Maternal weight (kg) | Minimum | 50 | 50 | 51 | 50 | 0.788 |
| Maximum | 60 | 59 | 58 | 60 | ||
| Mean±SD | 54.95±3.25 | 55.15±3.12 | 54.89±2.55 | 54.88±4.15 | ||
| Body mass index (kg/m) | Minimum | 21.12±0.15 | 20.51±0.11 | 21.35±0.11 | 21.12±0.15 | 0.055 |
| Maximum | 23.12±0.78 | 22.75±0.95 | 22.95±0.88 | 23.12±0.86 | ||
| Mean±SD | 22.11±0.32 | 22.05±0.51 | 22.15±0.48 | 22.21±0.61 | ||
| Educational status | Elementary school | 199 (51) | 54 (47) | 57 (52) | 88 (52) | 0.419 |
| Undergraduate | 133 (34) | 37 (32) | 38 (35) | 58 (35) | ||
| Graduate and above | 60 (15) | 24 (21) | 14 (13) | 22 (13) | ||
| History | Nullipara | 362 (92) | 97 (92) | 100 (92) | 155 (92) | 0.998 |
| Primipara | 26 (7) | 7 (7) | 8 (7) | 11 (7) | ||
| Multipara | 4 (1) | 1 (1) | 1 (1) | 2 (1) | ||
| Uterine scar | Yes | 252 (64) | 72 (63) | 71 (65) | 109 (65) | 0.803 |
| No | 140 (36) | 43 (37) | 38 (35) | 59 (35) | ||
| Time in labor room (min) | Minimum | 70 | 65 | 66 | 70 | 0.196 |
| Maximum | 55 | 55 | 56 | 58 | ||
| Mean±SD | 60.55±4.24 | 60.12±4.15 | 60.45±4.66 | 61.01±3.85 | ||
| Neonatal sex | Male | 214 (55) | 64 (56) | 61 (56) | 89 (53) | 0.856 |
| Female | 178 (45) | 51 (44) | 48 (44) | 79 (47) | ||
| Neonatal weight (kg) | 2.63±0.25 | 2.58±0.26 | 2.66±0.31 | 2.61±0.25 | 0.084 | |
| 1-minute Apgar score | 8.45±1.5 | 8.40±1.5 | 8.5±1.5 | 8.45±1.5 | 0.883 | |
| 5-minute Apgar score | 9.50±1 | 9.45±1 | 9.55±1 | 9.50±1 | 0.756 | |
| Categorical data are shown as a frequency (percentage) and continuous data are shown as mean±SD. One-way analysis of variance for continuous data and Fisher’s exact test for constant data and ordinal data were performed for statistical analysis. P | ||||||