06 September 2020: Animal Study
Biological Network Model of Effect of Chronic Intermittent Hypoxia on Spermatogenesis in Rats
Jisheng Wang 12ABDE* , Xuefeng Gong 3ABEF* , Fanchao Meng 12ABCDEF* , Sheng Deng 12CDF , Hengheng Dai 12BF , Binghao Bao 12BE , Junlong Feng 12BF , Haisong Li 2AG* , Bin Wang 2AE*DOI: 10.12659/MSM.925579
Med Sci Monit 2020; 26:e925579
Table 2 Top 10 key targets.
| Rank | Name | Score |
|---|---|---|
| 1 | Insulin (INS) | 27 |
| 2 | AKT serine/threonine kinase 1(AKT1) | 26 |
| 2 | Insulin-like growth factor 1 (IGF1) | 26 |
| 2 | Albumin (ALB) | 26 |
| 5 | Vascular endothelial growth factor A (VEGFA) | 24 |
| 5 | Tumor protein P53 (TP53) | 24 |
| 7 | Brain derived neurotrophic factor (BDNF) | 23 |
| 7 | Leptin (LEP) | 23 |
| 7 | Interleukin 6 (IL-6) | 23 |
| 10 | Tumor necrosis factor (TNF) | 22 |
| Key targets were screened using the Cytoscape plug-in cytoHubba. | ||