02 November 2020>: Lab/In Vitro Research
Detecting Rare Variants and Heteroplasmy of Mitochondrial DNA from High-Throughput Sequencing in Patients with Coronary Artery Disease
Qian Jia 12ABE* , Lu Xu 1CE* , Juan Shen 3CD , Yanping Wei 3CD , Huaiqian Xu 3B , Jionglong Shi 24D , Zhilong Jia 24D , Xiaojing Zhao 12D , Chunlei Liu 12D , Qin Zhong 12F , Yaping Tian 1AD* , Kunlun He 12A*DOI: 10.12659/MSM.925401
Med Sci Monit 2020; 26:e925401
Table 6 The power analysis result calculated by the Power Calculator based on the study design. The population disease prevalence was 0.05 and the significance level was 0.00125.
Genotype relative risk | Power (185 cases vs. 2704+180 controls) | |
---|---|---|
MAF=0.002 | 2.00 | 0.005 |
3.00 | 0.015 | |
3.50 | 0.022 | |
4.00 | 0.032 | |
4.50 | 0.043 | |
5.00 | 0.056 | |
6.00 | 0.086 | |
7.00 | 0.123 | |
8.00 | 0.166 | |
9.00 | 0.212 | |
10.00 | 0.262 | |
MAF=0.005 | 2.00 | 0.01 |
3.00 | 0.06 | |
3.50 | 0.10 | |
4.00 | 0.14 | |
4.50 | 0.19 | |
5.00 | 0.25 | |
6.00 | 0.38 | |
7.00 | 0.50 | |
8.00 | 0.61 | |
9.00 | 0.71 | |
10.00 | 0.79 | |
MAF=0.01 | 2.00 | 0.04 |
3.00 | 0.18 | |
3.50 | 0.29 | |
4.00 | 0.41 | |
4.50 | 0.52 | |
5.00 | 0.63 | |
6.00 | 0.79 | |
7.00 | 0.89 | |
8.00 | 0.95 | |
9.00 | 0.98 | |
10.00 | 0.99 |