02 November 2020: Lab/In Vitro Research
Detecting Rare Variants and Heteroplasmy of Mitochondrial DNA from High-Throughput Sequencing in Patients with Coronary Artery Disease
Qian Jia 12ABE* , Lu Xu 1CE* , Juan Shen 3CD , Yanping Wei 3CD , Huaiqian Xu 3B , Jionglong Shi 24D , Zhilong Jia 24D , Xiaojing Zhao 12D , Chunlei Liu 12D , Qin Zhong 12F , Yaping Tian 1AD* , Kunlun He 12A*DOI: 10.12659/MSM.925401
Med Sci Monit 2020; 26:e925401
Table 1 Baseline clinical characteristics of all participants.
| Discovery stage | Validation stage | |||||
|---|---|---|---|---|---|---|
| Control (n=80) | CHD (n=85) | P | Control (n=100) | CHD (n=100) | P | |
| Age | 63.10±10.69 | 63.07±11.42 | 0.763 | 62.27±11.22 | 65.11±12.26 | 0.524 |
| Male n (%) | 55 (68.75) | 63 (74.12) | 0.445 | 61 (61.00) | 72 (72.00) | 0.134 |
| SBP(mmHg) | 123.39±14.36 | 129.56±13.54 | 0.079 | 126.61±15.33 | 131.12±14.12 | 0.145 |
| DBP(mmHg) | 71.31±9.54 | 74.62±9.21 | 0.316 | 72.45±10.21 | 76.01±9.94 | 0.202 |
| BMI(kg/m) | 24.72±3.73 | 25.07±3.27 | 0.522 | 23.17±2.17 | 24.88±3.15 | 0.674 |
| Biochemical | ||||||
| ALT (U/L) | 18.85±7.33 | 24.74±11.66 | 0.085 | 17.53±9.42 | 23.57±14.57 | 0.087 |
| AS T(U/L) | 19.16±9.84 | 21.05±12.62 | 0.161 | 18.64±8.27 | 22.32±11.39 | 0.090 |
| TBIL (ummol/L) | 11.71±5.62 | 11.42±4.91 | 0.657 | 10.79±5.42 | 12.68±4.53 | 0.532 |
| DBIL (ummol/L) | 3.77±1.86 | 3.35±1.96 | 0.474 | 3.55±1.63 | 3.82±1.38 | 0.573 |
| Cr (umol/L) | 70.14±18.05 | 89.96±35.37 | 0.181 | 73.26±18.31 | 86.56±23.53 | 0.287 |
| BUN (mmo/L) | 5.51±2.40 | 6.44±2.60 | 0.069 | 5.69±2.15 | 6.24±2.93 | 0.182 |
| UA (mmo/L) | 374.27±28.53 | 397.48±32.86 | 0.672 | 356.35±26.61 | 403.93±30.70 | 0.378 |
| TG (mmol/L) | 1.52±0.63 | 1.61±0.96 | 0.091 | 1.59±0.41 | 1.66±0.85 | 0.176 |
| T-CH (mmol/L) | 3.93±0.92 | 4.22±1.11 | 0.884 | 3.47±0.78 | 4.52±1.36 | 0.640 |
| HDL (mmol/L) | 1.13±0.33 | 1.05±0.34 | 0.406 | 1.16±0.37 | 1.05±0. 43 | 0.346 |
| LDL (mmol/L) | 2.40±0.81 | 2.63±0.85 | 0.862 | 2.42±0.87 | 2.72±0.90 | 0.603 |
| GLU (mmol/L) | 5.22±1.36 | 5.73±1.84 | 0.257 | 5.07±0.93 | 6.17±2.15 | * |
| SOD (U/mL) | 155.29±17.48 | 136.54±20.62 | 0.010* | 156.38±21.58 | 137.31±19.24 | 0.026* |
| Data are expressed as means±standard deviation or percentages as appropriate. ALT – alanine aminotransferase; AST – aspartate aminotransferase; TBIL – total bilirubin; DBIL – direct bilirubin; Cr – creatinine; BUN – blood urea nitrogen; UA – uric acid; TG – triglyceride; T-CH – total cholesterol; HDL – high-density lipoprotein; LDL – low-density lipoprotein; GLU – glucose; SOD – superoxide dismutase. * | ||||||