Comparison of Bispectral Index-Guided Individualized Anesthesia with Standard General Anesthesia on Inadequate Emergence and Postoperative Delirium in Elderly Patients Undergoing Esophagectomy: A Retrospective Study at a Single Center

01 October 2020: Database Analysis

Yichen Yang ^1ACDEF* , Chengjun Song ^2BCDEF* , Chengwei Song ^2ACDEF , Chengwen Li ^3ACDEFG*

DOI: 10.12659/MSM.925314

Med Sci Monit 2020; 26:e925314

Table 5 Univariate and multivariate analyses of factors associated with postoperative delirium (PD) in the entire cohort.

variable	Univariate			Multivariate
variable	OR	95% CI	P-value	OR	95% CI	P-value
Individualized standard anesthesia	0.592	0.251–1.398	0.232
Age	1.113	1.016–1.220	0.021
BMI	0.992	0.869–1.132	0.902
Gender (Male Female)	0.711	0.308–1.643	0.425
ASA classification ≥3	4.328	1.655–11.318	0.003
Organic brain disease	6.767	2.761–16.585	0.000	6.308	2.458–16.187	0.000
Minimally invasive approach	0.522	0.208–1.310	0.166
Anesthesia technique
GA	1	Referent
GA+EA	0.570	0.231–1.406	0.222
GA+PVB	0.916	0.277–3..031	0.886
Duration of anesthesia	1.001	0.995–1.008	0.685
Duration of surgery	1.002	0.995–1.009	0.623
Intraoperative fluid infusion	1.000	0.999–1.001	0.983
BIS baseline	0.887	0.797–0.989	0.030
BIS minimal during surgery	1.026	0.978–1.076	0.296
BIS maximal during surgery	0.989	0.938–1.043	0.688
Hypertension during surgery	0.592	0.251–1.398	0.232
Hypotension during surgery	1.991	0.850–4.664	0.113
Inadequate emergence	4.370	1.866–10.234	0.001	4.063	1.645–10.033	0.002
Perioperative blood transfusion	2.913	1.045–8.120	0.041
PD – postoperative delirium; BMI – body weight index; ASA – American Society of Anesthesiologist; GA – general anesthesia; PVB – paravertebral block; EA – epidural anesthesia; BIS – bispectral index; OR – odd ratios; CI – confidence intervals.