18 October 2020>: Clinical Research
Expression of Matrix Metalloproteinase-2, Matrix Metalloproteinase-9, Tissue Inhibitor of Metalloproteinase-1, and Changes in Alveolar Septa in Patients with Chronic Obstructive Pulmonary Disease
Yongxiang Zhang ABCDE , Yuechuan Li AEFG* , Zhen Ye BD , Hui Ma CFDOI: 10.12659/MSM.925278
Med Sci Monit 2020; 26:e925278
Table 4 Comparison of alveolar septum thickness and fiber ratio between COPD group and control group.
Groups | Control (n=20) | COPD | |||
---|---|---|---|---|---|
Total (n=40) | Mild (n=8) | Moderate (n=24) | Severe (n=8) | ||
Thickness(um) | 5.63±1.87 | 6.90±2.11* | 6.19±1.65 | 6.44±1.75 | 9.00±2.39,,** |
Collagenous fiber (%) | 39.26±10.55 | 47.60±12.62* | 40.88±13.24 | 45.88±9.64 | 59.50±13.52,,** |
Elastic fibers (%) | 45.31±8.08 | 37.43±12.96* | 40.38±11.70 | 39.63±13.26 | 27.88±9.51,,** |
Elasticity/collagen | 108.54±37.85 | 82.87±38.85* | 107.55±41.10 | 88.86±35.13 | 48.38±17.97,,** |
COPD – chronic obstructive pulmonary disease; DLCO – carbon monoxide diffusing capacity; Control group, * ** # ## & && |