18 August 2020: Clinical Research
Effects of a Secondary Prevention Combination Therapy with beta-Blocker and Statin on Major Adverse Cardiovascular Events in Acute Coronary Syndrome Patients
Ling Zhu 12ABCDEFG , Qianwei Cui 1BCEF , Ying Liu 3BCEF , Zhongwei Liu 1BCE , Yong Zhang 1BCF , Fuqiang Liu 1ACDEFG* , Junkui Wang 1ACDEFG*DOI: 10.12659/MSM.925114
Med Sci Monit 2020; 26:e925114
Supplementary Table 1 Baseline clinical characteristics of patients with MACE.
| Total | MACE (+) | MACE (–) | P value | |
|---|---|---|---|---|
| n=636 | n=98 | n=538 | ||
| Age, year | 60.42±9.83 | 59.97±9.28 | 60.50±9.93 | 0.584 |
| Male, n% | 425 (66.8) | 69 (70.4) | 356 (66.2) | 0.484 |
| Heart rate, bpm | 69.56±10.16 | 69.77±10.36 | 68.42±9.00 | 0.206 |
| SBP, mmHg | 129.98±17.37 | 129.38±18.35 | 130.09±17.20 | 0.812 |
| DBP, mmHg | 78.21±10.69 | 78.01±9.69 | 78.25±10.87 | 0.802 |
| BMI, kg/m | 26.08±2.93 | 26.11±2.80 | 26.07±2.95 | 0.582 |
| Smoking, n% | 331 (52.0) | 54 (55.1) | 277 (51.5) | 0.583 |
| Old MI, n% | 66 (10.4) | 9 (9.2) | 57 (10.6) | 0.857 |
| Diabetes, n% | 165 (25.9) | 23 (23.5) | 142 (26.4) | 0.617 |
| Hypertension, n% | 405 (63.7) | 66 (67.3) | 339 (63.0) | 0.427 |
| Atrial fibrillation, n% | 21 (3.3) | 2 (2.0) | 19 (3.5) | 0.757 |
| CRE, umol/L | 79.77±19.14 | 79.18±15.79 | 79.88±19.71 | 0.725 |
| UA, umol/L | 304.70±80.08 | 299.38±79.21 | 305.67±80.28 | 0.627 |
| TG, mmol/L | 1.69±1.08 | 1.71±0.99 | 1.69±1.10 | 0.532 |
| TC, mmol/L | 4.17±1.04 | 4.27±1.07 | 4.16±1.04 | 0.241 |
| LDL, mmol/L | 2.36±0.88 | 2.45±0.85 | 2.34±0.89 | 0.131 |
| HDL, mmol/L | 1.06±0.27 | 1.03±0.25 | 1.06±0.27 | 0.308 |
| LVEDD, mm | 48.02±4.59 | 48.40±4.74 | 47.94±4.57 | 0.537 |
| LVEF,% | 62.37±6.58 | 62.51±6.94 | 62.35±6.51 | 0.877 |
| Aspirin, n% | 612 (96.2) | 96 (98.0) | 516 (95.9) | 0.562 |
| clopidogrel, n% | 453 (71.2) | 78 (79.6) | 375 (69.7) | 0.052 |
| ACEI or ARB, n% | 356 (56.0) | 53 (54.1) | 303 (56.3) | 0.740 |
| Revascularization, n%* | 463 (72.8) | 81 (82.7) | 382 (71.0) | 0.019 |
| Continuous variables are presented as mean±SD; categorical variables are presented as numbers or percentages. ACEI – angiotensin converting enzyme inhibitors; ARB – angiotensin receptor blocker; BMI – body mass index; CRE – creatinine; SBP – systolic blood pressure; DBP – diastolic blood pressure; HDL – high-density lipoprotein; LDL – low density lipoprotein; LVEDD – left ventricle end-diastolic diameter; LVEF – left ventricle ejection fraction; MI – myocardial infarction; SBP – systolic blood pressure; TC – total cholesterol; TG – triglyceride; UA – uric acid. * Included percutaneous coronary intervention and coronary artery bypass grafti. | ||||