Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B
(NF-kB)-Dependent Pathway

03 September 2020: Clinical Research

Positive Cross-Talk Between CXC Chemokine Receptor 4 (CXCR4) and Epidermal Growth Factor Receptor (EGFR) Promotes Gastric Cancer Metastasis via the Nuclear Factor kappa B (NF-κB)-Dependent Pathway

Yu Cheng ^123ABCDEG , Xiaofang Che ^123A , Simeng Zhang ^123C , Tianshu Guo ^123F , Xin He ^123F , Yunpeng Liu ^123AG* , Xiujuan Qu ^123AG*

DOI: 10.12659/MSM.925019

Med Sci Monit 2020; 26:e925019

Table 1 Correlation between CXCR4/EGFR levels and clinicopathological factors in patients with primary GC.

Factors	All cases	EGFR		P value	CXCR4		P value
Factors	All cases	Negative	Positive	P value	Negative	Positive	P value
Gender
Female	14	11	3		5	9
Male	42	28	14	0.513	17	25	0.752
Age
	28	20	8		10	18
≥60	28	19	9	1.000	12	16	0.584
Depth of invasion
T1+T2	9	9	0		5	4
T3+T4	47	30	17	0.045^*	17	30	0.294
Tumor size
≥5 cm		18	7		10	19
		21	10	0.730	12	15	0.922
Lymphovascular invasion
Yes		13	6		5	14
No		26	11	0.887	17	20	0.154
LN metastasis
N0	16	15	1		10	6
N1–3	40	24	16	0.022^*	12	28	0.024^*
Lauren classification
Intestinal	22	14	8		8	14
Diffuse	21	16	5		8	13
mixed	13	9	4	0.670	6	7	0.840
LN – lymph node. ^* P