11 August 2020: Database Analysis
Early Death Incidence and Prediction in Stage IV Breast Cancer
Yumei Zhao 1BE , Guijun Xu 2B , Xinpeng Guo 1F , Wenjuan Ma 1CG , Yao Xu 2C , Karl Peltzer 3F , Vladimir P. Chekhonin 4E , Vladimir P. Baklaushev 5D , Nan Hu 6DG , Xin Wang 7DG , Zheng Liu 28A* , Chao Zhang 2AG*DOI: 10.12659/MSM.924858
Med Sci Monit 2020; 26:e924858
Table 1 Description of the early death for patients with IV breast cancer in the construction cohort.
| Subject characteristics | Patients No. (%) | |||
|---|---|---|---|---|
| No early death | Total early death | Cancer specific early death | Non-cancer specific early death | |
| Age | ||||
| 2790 (22.5) | 645 (10.8) | 521 (11.8) | 124 (7.8) | |
| 50–59 | 3256 (26.2) | 1178 (19.6) | 923 (20.9) | 255 (16.1) |
| 60–69 | 3267 (26.3) | 1506 (25.1) | 1128 (25.5) | 378 (23.9) |
| 70–79 | 1952 (15.7) | 1318 (22.0) | 940 (21.3) | 378 (23.9) |
| ≥80 | 1143 (9.2) | 1351 (22.5) | 904 (20.5) | 447 (28.3) |
| Marital status | ||||
| Married | 5790 (46.7) | 1993 (33.2) | 1477 (33.4) | 516 (32.6) |
| Unmarried | 5922 (47.7) | 3674 (61.3) | 2697 (61.1) | 977 (61.8) |
| Unknown | 696 (5.6) | 331 (5.5) | 242 (5.5) | 89 (5.6) |
| Race | ||||
| White | 9466 (76.3) | 4409 (73.5) | 3252 (73.6) | 1157 (73.1) |
| Black | 1906 (15.4) | 1208 (20.1) | 881 (20) | 327 (20.7) |
| Others | 987 (8.0) | 369 (6.2) | 274 (6.2) | 95 (6.0) |
| Unknown | 49 (0.4) | 12 (0.2) | 9 (0.2) | 3 (0.2) |
| Insurance | ||||
| Insured | 11727 (94.5) | 5527 (92.1) | 4033 (91.3) | 1494 (94.4) |
| Uninsured | 437 (3.5) | 308 (5.1) | 265 (6.0) | 43 (2.7) |
| Unknown | 244 (2.0) | 163 (2.7) | 118 (2.7) | 45 (2.8) |
| Subtypes | ||||
| Luminal A | 7274 (58.6) | 2295 (38.3) | 1645 (37.3) | 650 (41.1) |
| Luminal B | 1961 (15.8) | 544 (9.1) | 427 (9.7) | 117 (7.4) |
| HER2 enriched | 891 (7.2) | 424 (7.1) | 323 (7.3) | 101 (6.4) |
| Triple negative | 908 (7.3) | 1164 (19.4) | 871 (19.7) | 293 (18.5) |
| Unknown | 1374 (11.1) | 1571 (26.2) | 1150 (26) | 421 (26.6) |
| Grade | ||||
| Grade I | 979 (7.9) | 212 (3.5) | 140 (3.2) | 72 (4.6) |
| Grade II | 4401 (35.5) | 1432 (23.9) | 1021 (23.1) | 411 (26) |
| Grade III | 4220 (34.0) | 2220 (37.0) | 1689 (38.2) | 531 (33.6) |
| Grade IV | 56 (0.5) | 45 (0.8) | 37 (0.8) | 8 (0.5) |
| Unknown | 2752 (22.2) | 2089 (34.8) | 1529 (34.6) | 560 (35.4) |
| Tumor site | ||||
| UOQ | 2930 (23.6) | 1141 (19) | 832 (18.8) | 309 (19.5) |
| LOQ | 684 (5.5) | 226 (3.8) | 162 (3.7) | 64 (4.0) |
| LIQ | 453 (3.7) | 154 (2.6) | 104 (2.4) | 50 (3.2) |
| UIQ | 794 (6.4) | 284 (4.7) | 204 (4.6) | 80 (5.1) |
| CEN | 761 (6.1) | 288 (4.8) | 212 (4.8) | 76 (4.8) |
| Others | 2577 (20.8) | 1059 (17.7) | 767 (17.4) | 292 (18.5) |
| Unknown | 4209 (33.9) | 2846 (47.4) | 2135 (48.3) | 711 (44.9) |
| Laterality | ||||
| Left-sided | 6030 (48.6) | 2848 (47.5) | 2110 (47.8) | 738 (46.6) |
| Right-sided | 5799 (46.7) | 2684 (44.7) | 1972 (44.7) | 712 (45.0) |
| One side, NOS | 51 (0.4) | 35 (0.6) | 29 (0.7) | 6 (0.4) |
| Paired sides | 528 (4.3) | 431 (7.2) | 305 (6.9) | 126 (8.0) |
| Tumor size | ||||
| 0–2 cm | 1937 (15.6) | 705 (11.8) | 438 (9.9) | 267 (16.9) |
| 2–5 cm | 4721 (38.0) | 1871 (31.2) | 1346 (30.5) | 525 (33.2) |
| >5 cm | 3263 (26.3) | 1580 (26.3) | 1274 (28.8) | 306 (19.3) |
| Unknown | 2487 (20.0) | 1842 (30.7) | 1358 (30.8) | 484 (30.6) |
| N stage | ||||
| N0 | 2860 (23.0) | 1490 (24.8) | 991 (22.4) | 499 (31.5) |
| N1 | 4321 (34.8) | 1634 (27.2) | 1266 (28.7) | 368 (23.3) |
| N2 | 1131 (9.1) | 370 (6.2) | 276 (6.3) | 94 (5.9) |
| N3 | 3092 (24.9) | 1613 (26.9) | 1237 (28) | 376 (23.8) |
| Unknown | 1004 (8.1) | 891 (14.9) | 646 (14.6) | 245 (15.5) |
| Bone Met | ||||
| No | 3562 (28.7) | 2156 (35.9) | 1525 (34.5) | 631 (39.9) |
| Yes | 8846 (71.3) | 3842 (64.1) | 2891 (65.5) | 951 (60.1) |
| Brain Met | ||||
| No | 11786 (95.0) | 5178 (86.3) | 3792 (85.9) | 1386 (87.6) |
| Yes | 622 (5.0) | 820 (13.7) | 624 (14.1) | 196 (12.4) |
| Liver Met | ||||
| No | 9722 (78.4) | 3820 (63.7) | 2712 (61.4) | 1108 (70) |
| Yes | 2686 (21.6) | 2178 (36.3) | 1704 (38.6) | 474 (30) |
| Lung Met | ||||
| No | 8861 (71.4) | 3527 (58.8) | 2521 (57.1) | 1006 (63.6) |
| Yes | 3547 (28.6) | 2471 (41.2) | 1895 (42.9) | 576 (36.4) |
| Surgery | ||||
| No surgery | 8177 (65.9) | 5094 (84.9) | 3785 (85.7) | 1309 (82.7) |
| PM | 1174 (9.5) | 298 (5.0) | 195 (4.4) | 103 (6.5) |
| TM | 984 (7.9) | 201 (3.4) | 132 (3) | 69 (4.4) |
| RM | 1851 (14.9) | 339 (5.7) | 251 (5.7) | 88 (5.6) |
| Others | 38 (0.3) | 9 (0.2) | 5 (0.1) | 4 (0.3) |
| Unknown | 184 (1.5) | 57 (1.0) | 48 (1.1) | 9 (0.6) |
| UOQ – upper outer quadrant; LOQ – lower outer quadrant; LIQ – lower inner quadrant; UIQ – upper inner quadrant; CEN – central portion; NOS – not otherwise specified; PM – partial mastectomy; TM – total mastectomy; RM – radical mastectomy. | ||||